Home > Organophosphorus Compounds> (2R,4S)-2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ<sup>5</sup>-oxazaphosphinan-4-ol

(2R,4S)-2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ<sup>5</sup>-oxazaphosphinan-4-ol

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Origin: China

Cas No: 61903-30-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 61903-30-8 Formula: C7H15Cl2N2O3P Molecular Weight: 277.08500

Description

A metabolite of Cyclophosphamide. This Kit consists of a vial of the precursor, 4-hydroperoxycyclophosphamide, and a vial of sodium thiosulfate. Simply add water to the reducing agent until it is completely dissolved and add this solution to the precursor. This solution has a half-life of approximately 200 minutes at room temperature. Detailed instructions are enclosed.

Basic Info

Chemical Name	(2R,4S)-2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ<sup>5</sup>-oxazaphosphinan-4-ol
Synonyms	cis-4-hydroxycyclophosphamide; (R,S)-4-Hydroxy Cyclophosphamide,Preparation Kit; (2R,4S)-rel-2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-4-ol 2-Oxide;
CAS No.	61903-30-8
Molecular Formula	C7H15Cl2N2O3P
Molecular Weight	277.08500
PSA	71.61000
LogP	1.53120

Properties

Stability	This solution is stable for one day at room temperature
Storage Condition	Hygroscopic, -86ºC Freezer, Under Inert Atmosphere

Synthesis Route

3-[amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanal→aldophosphamide hydrate+(2R,4R)-2-(bis(2-chloroethyl)amino)-4-hydroxy-1,3,2-oxazaphosphinane 2-oxide
cis-Mosfosfamide→3-[amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanal+aldophosphamide hydrate
4-hydroperoxycyclophosphamide→phosphoramide mustard+3-[amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanal

Precursor

4-hydroperoxycyclophosphamide
3-[amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanal
cis-Mosfosfamide

Downstream Product

3-[amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanal
aldophosphamide hydrate

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