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(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl dihydrogen phosphate

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начало: Китай

Кас Но: 93390-81-9

Спецификация: 99%наименьший

минимальный объем заказа: 1 /kg

снабженческая способность: 50 mt/month

опережающий период: OEM 7 дней, пятно 3 дня

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CAS No.: 93390-81-9 Formula: C16H15N2O6P Molecular Weight: 362.27400

Description

Fosphenytoin (fosphenytoin sodium injection, previously Cerebyx, Parke-Davis; Prodilantin, Pfizer Holding France) is a water-soluble phenytoin prodrug that is administered intravenously to deliver phenytoin, potentially more safely than intravenous phenytoin. It is most commonly used in the acute treatment convulsive status epilepticus.
Fosphenytoin was developed in 1996. On 18 November 2004, Sicor (a subsidiary of Teva) received a tentative approval letter from the United States Food and Drug Administration for a generic version of fosphenytoin.

Basic Info

Chemical Name	(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl dihydrogen phosphate
Synonyms	Prodilantin; Fosphenytoin; 3-Phosphoryloxymethyl-diphenylhydantoin; 3-phosphoryloxymethyl-5,5-diphenylhydantoin; fosphenyloin; Fosfenitoina; HMPDP; Fosphenytoine; oxcarbamazepine; Fosphenytoinum;
CAS No.	93390-81-9
Molecular Formula	C16H15N2O6P
Molecular Weight	362.27400
PSA	125.98000
LogP	1.81550

Properties

Density	1.495g/cm3
Refractive Index	1.63

Safety Info

HS Code	2933990090

Synthesis Route

phosphoric acid dibenzyl ester 2,5-dioxo-4,4-diphenylimidazolidin-1-ylmethyl ester→(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl dihydrogen phosphate
phenytoin→(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl dihydrogen phosphate
3-(chloromethyl)-5,5-diphenylimidazolidine-2,4-dione→(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl dihydrogen phosphate

Precursor

3-(hydroxymethyl)-5,5-diphenylimidazolidine-2,4-dione
3-(chloromethyl)-5,5-diphenylimidazolidine-2,4-dione
phenytoin
phosphoric acid dibenzyl ester 2,5-dioxo-4,4-diphenylimidazolidin-1-ylmethyl ester

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