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2,5-Difluorobenzyl bromide

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Origin: China

Cas No: 85117-99-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 85117-99-3 Formula: C7H5BrF2 Molecular Weight: 207.01500

Description

2,5-Difluorobenzyl Bromide is used as a reagent in the synthesis of phthalazinone pyrazoles as potent inhibitors of Aurora-A kinase. Also used as a reagent in the synthesis of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase.

Basic Info

Chemical Name	2,5-Difluorobenzyl bromide
Synonyms	2-(bromomethyl)-1,4-difluorobenzene;
CAS No.	85117-99-3
Molecular Formula	C7H5BrF2
Molecular Weight	207.01500
PSA	0.00000
LogP	2.85970

Properties

Appearance & Physical State	Clear yellow liquid.
Density	1.609
Boiling Point	28ºC
Melting Point	8ºC
Flash Point	15ºC
Refractive Index	1.5246-1.5266
Stability	Stable at room temperature in closed containers under normal storage and handling conditions.
Storage Condition	Flammables area

Safety Info

Hazard Class	8
Safety Statements	S16-S26-S36/37/39-S45
Packing Group	III
WGK Germany	3
RIDADR	UN 2924
Risk Statements	R11; R22; R34
Hazard Codes	F; C
Signal Word	Danger
Caution Statement	P210; P280; P305 + P351 + P338; P310
Symbol	GHS02, GHS05
Hazard Declaration	H225; H314

Synthesis Route

2,5-Difluorotoluene→2,5-Difluorobenzyl bromide

Precursor

2,5-Difluorotoluene

Downstream Product

cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid
(2S)-2-amino-3-(2,5-difluorophenyl)propanoic acid
(2R)-2-acetamido-3-(2,5-difluorophenyl)propanoic acid
(2R)-3-(2,5-difluorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid

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