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Home > Organophosphorus Compounds> 2,2,2-trichloroethyl dihydrogen phosphate
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2,2,2-trichloroethyl dihydrogen phosphate

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Origin: China

Cas No: 306-52-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 306-52-5 Formula: C2H4Cl3O4P Molecular Weight: 229.38400

    Description

    Triclofos is a sedative drug used rarely for treating insomnia, usually as a second-line treatment after other drugs have failed. Triclofos may cause dependence and should not be withdrawn suddenly. This drug should only be used for the short term relief of severe insomnia and should not be mixed with alcohol or other depressant drugs. Patients should not drive or use machinery after taking triclofos.
    Triclofos is a prodrug which is metabolised in the liver into the active drug trichloroethanol. This delayed action means that the half-life of triclofos is fairly long and it may cause drowsiness the next day. Trichloroethanol may cause liver damage and triclofos should not be used for extended periods.

    Basic Info

    Chemical Name 2,2,2-trichloroethyl dihydrogen phosphate
    Synonyms

    phosphoric acid mono-(2,2,2-trichloro-ethyl) ester;
    Triclofos [INN:BAN];
    2,2,2-trichloroethylphosphate;
    triclofos;
    Triclofosum [INN-Latin];
    Tricloryl;
    2,2,2-trichloroethyl dihydrogenphosphate;
    Trichloroethyl phosphate;
    Trichlophos;
    Triclos;
    Trichloryl;
    O-2,2,2-trichloroethyl monophosphate;
    Triclofoso [DCIT];

    CAS No. 306-52-5
    Molecular Formula C2H4Cl3O4P
    Molecular Weight 229.38400
    PSA 76.57000
    LogP 1.46590

    Properties

    Density 1.891 g/cm3
    Boiling Point 321.2ºC at 760 mmHg
    Flash Point 148.1ºC
    Refractive Index 1.53

    Safety Info

    HS Code 2919900090

    Synthesis Route

    2,2,2-trichloroethanol→2,2,2-trichloroethyl dihydrogen phosphate
    2-(2,2,2-trichloro-ethoxy)-[1,3,2]dioxaphospholane 2-oxide→2,2,2-trichloroethyl dihydrogen phosphate
    phosphoric acid 2-hydroxy-phenyl ester 2,2,2-trichloro-ethyl ester; triethylamine salt→2,2,2-trichloroethyl dihydrogen phosphate

    Precursor

    phosphoric acid 2-hydroxy-phenyl ester 2,2,2-trichloro-ethyl ester; triethylamine salt
    phosphorus trichloride
    2-(2,2,2-trichloro-ethoxy)-[1,3,2]dioxaphospholane 2-oxide
    2,2,2-trichloroethanol

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