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2,2-bis(4-fluorophenyl)-2-phenylacetamide

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Origin: China

Cas No: 289656-45-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 289656-45-7 Formula: C20H15F2NO Molecular Weight: 323.33600

Description

Senicapoc (ICA-17043) is a Gardos channel blocker.
It has been proposed for use in sickle cell anemia.
The Gardos channel has been identified as KCNN4.
The "ICA" is for Icagen, which is developing the drug.

Basic Info

Chemical Name	2,2-bis(4-fluorophenyl)-2-phenylacetamide
Synonyms	Senicapoc; UNII-TS6G201A6Q;
CAS No.	289656-45-7
Molecular Formula	C20H15F2NO
Molecular Weight	323.33600
PSA	43.09000
LogP	4.48480

Properties

Density	1.25g/cm3
Boiling Point	460.7ºC at 760mmHg
Flash Point	232.4ºC
Refractive Index	1.594
Vapor Pressure	1.14E-08mmHg at 25°C

Safety Info

HS Code	2924299090

Synthesis Route

bis(4-fluorophenyl)methanone→2,2-bis(4-fluorophenyl)-2-phenylacetamide
phenylmagnesium bromide→2,2-bis(4-fluorophenyl)-2-phenylacetamide
bis(4-fluorophenyl)methanone→2,2-bis(4-fluorophenyl)-2-phenylacetamide+bis-(4-fluoro-phenyl)-phenyl-methane

Precursor

phenylmagnesium bromide
bis(4-fluorophenyl)-phenylmethanol
bis(4-fluorophenyl)methanone

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