Início > Organosilicon Compounds> 2-Methyl-2-propanyl (2S,4R)-4-{[dimethyl(2-methyl-2-propanyl)sily l]oxy}-2-(hydroxymethyl)-1-pyrrolidinecarboxylate

2-Methyl-2-propanyl (2S,4R)-4-{[dimethyl(2-methyl-2-propanyl)sily l]oxy}-2-(hydroxymethyl)-1-pyrrolidinecarboxylate

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Origem: China

Cas No: 114676-67-4

Especificação: 99%Min

Quantidade de ordem min: 1 /kg

Capacidade de fornecimento: 100 mt/month

Tempo de espera: 7 dias para OEM, 3 dias para produtos prontos

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CAS No.: 114676-67-4 Formula: C16H33NO4Si Molecular Weight: 331.52300

Basic Info

Chemical Name	2-Methyl-2-propanyl (2S,4R)-4-{[dimethyl(2-methyl-2-propanyl)sily l]oxy}-2-(hydroxymethyl)-1-pyrrolidinecarboxylate
Synonyms	Simvastatin acid ammonium; simvastatin hydroxy acid,ammonium salt; Simvastatin Acid Ammonium Salt;
CAS No.	114676-67-4
Molecular Formula	C16H33NO4Si
Molecular Weight	331.52300
PSA	59.00000
LogP	3.31640

Synthesis Route

(2S,4R)-1-Boc-2-methylcarboxylate-4-tert-butyldimethylsilyloxy-pyrrolidine→2-Methyl-2-propanyl (2S,4R)-4-{[dimethyl(2-methyl-2-propanyl)sily l]oxy}-2-(hydroxymethyl)-1-pyrrolidinecarboxylate
1-tert-butyl 2-ethyl (2S,4R)-4-{[tert-butyl (dimethyl)silyl]oxy} pyrrolidine-1,2-dicarboxylate→2-Methyl-2-propanyl (2S,4R)-4-{[dimethyl(2-methyl-2-propanyl)sily l]oxy}-2-(hydroxymethyl)-1-pyrrolidinecarboxylate
tert-butoxycarbonyl anhydride→2-Methyl-2-propanyl (2S,4R)-4-{[dimethyl(2-methyl-2-propanyl)sily l]oxy}-2-(hydroxymethyl)-1-pyrrolidinecarboxylate

Precursor

1-tert-butyl 2-ethyl (2S,4R)-4-{[tert-butyl (dimethyl)silyl]oxy} pyrrolidine-1,2-dicarboxylate
tert-butyldimethylsilyl chloride
tert-butoxycarbonyl anhydride
(2S,4R)-1-Boc-2-methylcarboxylate-4-tert-butyldimethylsilyloxy-pyrrolidine

Downstream Product

(2R,4R)-N-Boc-4-hydroxy-2-methylpyrrolidine

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