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2-Chloro-5-fluoropyridine

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Origin: China

Cas No: 31301-51-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 31301-51-6 Formula: C5H3ClFN Molecular Weight: 131.53500

Description

2-Chloro-5-fluoropyridine, is the intermediate used for the synthesis of pharmaceuticals agents and biologically active compounds, such as pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors.

Basic Info

Chemical Name	2-Chloro-5-fluoropyridine
Synonyms	2-Chloro-5-fluoropyridin; 2-chloro-5-fluoro-pyridine; 2-chloro-5-fluropyridine; 2-Chlor-5-fluorpyridin;
CAS No.	31301-51-6
Molecular Formula	C5H3ClFN
Molecular Weight	131.53500
PSA	12.89000
LogP	1.87410

Properties

Appearance & Physical State	Light yellow powder
Density	1.297
Boiling Point	147.5ºC at 760 mmHg
Flash Point	108ºC
Refractive Index	1.503

Safety Info

Hazard Class	3
Safety Statements	S26-S36/39
HS Code	2933399090
WGK Germany	3
Packing Group	III
RIDADR	UN 1993
Risk Statements	R10; R22; R37/38; R41
Hazard Codes	Xn
Hazard Declaration	H226; H302; H315; H318; H335
Symbol	GHS02, GHS05, GHS07
Signal Word	Danger
Caution Statement	P261; P280; P305 + P351 + P338

Synthesis Route

5-Amino-2-chloropyridine→2-Chloro-5-fluoropyridine
5-Bromo-2-chloropyridine→2-Chloro-5-fluoropyridine
2-Chloro-5-iodopyridine→2-Chloro-5-fluoropyridine

Precursor

5-Bromo-2-chloropyridine
5-Amino-2-chloropyridine
2-Chloro-5-iodopyridine

Downstream Product

2-Chloro-5-fluoro-4-pyridinamine
2-Amino-5-fluoropyridine
2-Chloro-5-fluoropyridine-3,4-diamine
2-Chloro-5-fluoro-3-nitropyridin-4-amine

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