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2-chloro-1-(3-chlorophenyl)ethanone

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Origin: China

Cas No: 21886-56-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 21886-56-6 Formula: C8H6Cl2O Molecular Weight: 189.03900

Description

2,3'-Dichloroacetophenone is used as a reagent in the synthesis of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3β (GSK-3β). Also used as a reagent in the synthesis of benzimidazolyl pyridinones as insulin-like growth factor I (IGF-1R) kinase inhibitors.

Basic Info

Chemical Name	2-chloro-1-(3-chlorophenyl)ethanone
Synonyms	m-chlorophenacyl chloride; 2,3'-Dichloroacetophenone; 3-chlorophenyl chloromethyl ketone; \|A,3-Dichloroacetophenone; 2-Chloro-1-(3-chlorophenyl)ethanone; 3-chlorophenacyl chloride; 2-chloro-3'-chloroacetophenone; chloromethyl m-chlorophenyl ketone;
CAS No.	21886-56-6
Molecular Formula	C8H6Cl2O
Molecular Weight	189.03900
PSA	17.07000
LogP	2.76150

Properties

Density	1.31g/cm3
Boiling Point	283.7ºC at 760mmHg
Flash Point	118.2ºC
Refractive Index	1.55
Vapor Pressure	0.00311mmHg at 25°C

Safety Info

HS Code	2914700090
Hazard Codes	C

Synthesis Route

3-Chlorophenylacetylene+acetic acid→2-chloro-1-(3-chlorophenyl)ethanone+1-chloro-3-(2-chloroethynyl)benzene
3-Chlorophenylacetylene+acetic acid→2-chloro-1-(3-chlorophenyl)ethanone+1-chloro-3-(2-chloroethynyl)benzene
3-Bromochlorobenzene+Chloroacetyl chloride→2-chloro-1-(3-chlorophenyl)ethanone

Precursor

Chloroacetyl chloride
3-Chlorophenylacetylene
3-Bromochlorobenzene
3′-Chloroacetophenone

Downstream Product

(1S)-2-Chloro-1-(3-chlorophenyl)ethanol
2-chloro-1-(3-chlorophenyl)ethanol
3'-chloro-2-methoxyacetophenone
1-(3-chlorophenyl)-2-hydroxyethanone

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