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2-Amino-7-phosphonoheptanoic acid

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Origin: China

Cas No: 85797-13-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 85797-13-3 Formula: C7H16NO5P Molecular Weight: 225.17900

Description

AP-7 is a selective NMDA receptor (NMDAR) antagonist that competitively inhibits the glutamate binding site and thus activation of NMDAR. It has anticonvulsant effects.
AP-7 functions specifically as a NMDA recognition site blocker, in contrast with 7-chlorokynurenate, which acts as a glycine site modulation blocker.

Basic Info

Chemical Name	2-Amino-7-phosphonoheptanoic acid
Synonyms	DL-2-amino-5-phosphonovaleric acid; D-2-amino-5-phosphonovaleric acid; APV; AP-5; DL-APV; [3H]-DL-AP 5; 2-amino-5-phosphopentanoicacid; d-(+/-)-2-amino-5-phosphonopentanoic acid; (-)2-amino-7-phosphonoheptanoic acid; 2-amino-5-phosphonovaleric acid; acide amino-6 carboxy-6 hexylphosphonique; [3H]-DL-AP7; 5-PHOSPHONO-DL-NORVALINE; 2-amino-5-phosphovaleric acid;
CAS No.	85797-13-3
Molecular Formula	C7H16NO5P
Molecular Weight	225.17900
PSA	130.66000
LogP	0.83670

Properties

Density	1.39g/cm3
Boiling Point	480.1ºC at 760mmHg
Flash Point	244.2ºC

Safety Info

Safety Statements	S22; S24/25
HS Code	2931900090

Synthesis Route

(N-acetylamino-6 bis-ethoxycarbonyl-6,6)-hexylphosphonate de diethyle→2-Amino-7-phosphonoheptanoic acid
diethyl 2-acetamido-2-(5-bromopentyl)propanedioate→2-Amino-7-phosphonoheptanoic acid
2-Acetylamino-2-(5-phosphono-pentyl)-malonic acid diethyl ester→2-Amino-7-phosphonoheptanoic acid

Precursor

2-Acetylamino-2-(5-phosphono-pentyl)-malonic acid diethyl ester
diethyl 2-acetamido-2-(5-(dimethoxyphosphoryl)pentyl)malonate
(N-acetylamino-6 bis-ethoxycarbonyl-6,6)-hexylphosphonate de diethyle
diethyl 2-acetamido-2-(5-bromopentyl)propanedioate

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