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2-amino-5-phosphonopentanoic acid

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Origin: China

Cas No: 76326-31-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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CAS No.: 76326-31-3 Formula: C5H12NO5P Molecular Weight: 197.12600

Description

AP5 or APV ((2R)-amino-5-phosphonovaleric acid; (2R)-amino-5-phosphonopentanoate) is a selective NMDA receptor antagonist that competitively inhibits the ligand (glutamate) binding site of NMDA receptors. AP5 blocks NMDA receptors in micromolar concentrations (~50 µM).
AP5 blocks the cellular analog of classical conditioning in the sea slug Aplysia californica, and has similar effects on Aplysia long-term potentiation (LTP), since NMDA receptors are required for both. It is sometimes used in conjunction with the calcium chelator BAPTA to determine whether NMDARs are required for a particular cellular process. AP5/APV has also been used to study NMDAR-dependent LTP in the mammalian hippocampus.
In general, AP5 is very fast-acting within in vitro preparations, and can block NMDA receptor action at a reasonably small concentration. The active isomer of AP5 is considered to be the D configuration, although many preparations are available as a racemic mixture of D- and L-isomers. It is useful to isolate the action of other glutamate receptors in the brain, i.e., AMPA and kainate receptors.
AP5 can block the conversion of a silent synapse to an active one, since this conversion is NMDA receptor-dependent.
AP5 was developed by Jeff Watkins and Harry Olverman.

Basic Info

Chemical Name	2-amino-5-phosphonopentanoic acid
Synonyms	DL-2-amino-5-phosphonovaleric acid; D-2-amino-5-phosphonovaleric acid; 2-amino-5-phosphopentanoicacid; APV; AP-5; 2-amino-5-phosphonovaleric acid; DL-AP5; 5-PHOSPHONO-DL-NORVALINE; 2-amino-5-phosphovaleric acid; DL-APV;
CAS No.	76326-31-3
Molecular Formula	C5H12NO5P
Molecular Weight	197.12600
PSA	130.66000
LogP	0.05650

Properties

Appearance & Physical State	white fine crystalline powder
Density	1.529g/cm3
Boiling Point	482.1ºC at 760 mmHg
Flash Point	245.4ºC
Refractive Index	1.536
Storage Condition	Store at RT