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Picture of [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate

[2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate

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Origin: China

Cas No: 55981-09-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Quick Details

    CAS No.:
    55981-09-4
    Other Names:
    Nitazoxanide
    MF:
    C12H9N3O5S
    EINECS No.:
    /
    Place of Origin:
    Fujian, China
    Type:
    Antibiotic and Antimicrobial Agents
    Grade Standard:
    Medicine Grade
    Usage:
    Animal Pharmaceuticals
    Brand Name:
    SINOWAY
    Model Number:
    SINOWAY
    Purity:
    98%
    Product Name:
    Nitazoxanide

    Packaging&Delivery

    Packaging Details
    25kg/drum, or as your requirement
    Port
    Shanghai/jiangsu/Beijing/Xiamen
    Lead Time:
    Quantity(Kilograms)1 - 100>100
    Est. Time(days)7To be negotiated
  • Property

    CAS No.: 55981-09-4 Formula: C12H9N3O5S Molecular Weight: 307.28200

    Description

    Nitazoxanide is a broad-spectrum antiparasitic and broad-spectrum antiviral drug that is used in medicine for the treatment of various helminthic, protozoal, and viral infections. It is indicated for the treatment of infection by Cryptosporidium parvum and Giardia lamblia in immunocompetent individuals and has been repurposed for the treatment of influenza. Nitazoxanide has also been shown to have in vitro antiparasitic activity and clinical treatment efficacy for infections caused by other protozoa and helminths; emerging evidence suggests that it possesses efficacy in treating a number of viral infections as well.
    Chemically, nitazoxanide is the prototype member of the thiazolides, a class of drugs which are synthetic nitrothiazolyl-salicylamide derivatives with antiparasitic and antiviral activity. Tizoxanide, an active metabolite of nitazoxanide in humans, is also an antiparasitic drug of the thiazolide class.

    Basic Info

    Chemical Name [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate
    Synonyms

    Cryptaz;
    Heliton;
    Nitazoxanide;
    Nitazoxanidum;
    Alinia;
    Daxon;
    Nitazoxamide;
    Nitazoxanida;
    [14C]-Nitazoxanide;
    Colufase;

    CAS No. 55981-09-4
    Molecular Formula C12H9N3O5S
    Molecular Weight 307.28200
    PSA 142.35000
    LogP 2.82510

    Properties

    Appearance & Physical State Yellowish to white crystalline powder
    Density 1.532 g/cm3
    Melting Point 202ºC
    Storage Condition -20ºC Freezer

    Safety Info

    HS Code 2942000000
    Caution Statement P261; P305 + P351 + P338
    Signal Word Warning
    Hazard Declaration H302; H315; H319; H335
    Symbol GHS07

    Synthesis Route

    2-Amino-5-nitrothiazole+O-Acetylsalicylryl chloride[2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat >10 gm/kg 1.Behavioral-somnolence (general depressed activity)
    2.Behavioral-muscle weakness
    Oral LD50 - Lethal dose, 50 percent kill Rodent - mouse 1350 mg/kg 1.Behavioral-somnolence (general depressed activity)
    2.Behavioral-muscle weakness
    Oral LD - Lethal dose Mammal - dog >10 gm/kg 1.Autonomic Nervous System-smooth muscle relaxant (mechanism undefined, spasmolytic)

    Precursor

    O-Acetylsalicylryl chloride
    2-Amino-5-nitrothiazole

    Downstream Product

    2-hydroxy-N-(1,3-thiazol-2-yl)benzamide

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