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2-[4-(trifluoromethyl)phenyl]acetic acid

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Origin: China

Cas No: 32857-62-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
32857-62-8
Other Names:
4-(trifluoromethyl)phenylacetic
MF:
C9H6F3O2
Place of Origin:
Hunan, China
Type:
Pharmaceutical Intermediates
Brand Name:
EASCHEM
Model Number:
ESC9H6F3O2
Application:
Pharmaceutical intermediates
Appearance:
Powder, Powder
Packaging&Delivery
Packaging Details
Packed in paper drum or according to customer requirements.
Port
Shanghai port,Shenzhen port,Changsha port
Lead Time:
Quantity(Kilograms) 1 - 5 >5
Est. Time(days) 7 To be negotiated

Property

CAS No.: 32857-62-8 Formula: C9H7F3O2 Molecular Weight: 204.14600

Description

4-(Trifluoromethyl)benzeneacetic Acid is an intermediate used to synthesize PPARγ/δ dual agonists via solid-Phase parallel synthesis. It was also used to prepare heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists.

Basic Info

Chemical Name	2-[4-(trifluoromethyl)phenyl]acetic acid
Synonyms	4-trifluorometylphenylacetic acid; 4-(Trifluoromethyl)Phenylacetic Acid; (alpha,alpha,alpha-Trifluoro-p-tolyl)acetic acid; (α,α,α-Trifluoro-p-tolyl)acetic acid; 2-(4-(Trifluoromethyl)phenyl)acetic acid;
CAS No.	32857-62-8
Molecular Formula	C9H7F3O2
Molecular Weight	204.14600
PSA	37.30000
LogP	2.33250

Properties

Appearance & Physical State	white to very pale yellow crystals
Density	1.357g/cm3
Boiling Point	263.1ºC at 760mmHg
Melting Point	81-85ºC

Safety Info

Safety Statements	S26-S37/39
HS Code	2916399090
WGK Germany	3
Risk Statements	R36/37/38
Hazard Codes	Xi

Synthesis Route

carbon dioxide+4-Trifluoromethylbenzyl chloride→2-[4-(trifluoromethyl)phenyl]acetic acid
1-(pyrrolidin-1-yl)-2-(4-(trifluoromethyl)phenyl)ethan-1-one→2-[4-(trifluoromethyl)phenyl]acetic acid
2-[4-(carboxymethyl)phenyl]-2,2-difluoroacetic acid→p-Trifluormethyl-benzylfluorid+2-[4-(trifluoromethyl)phenyl]acetic acid

Precursor

Methyl [4-(trifluoromethyl)phenyl]acetate
carbon dioxide
1-(pyrrolidin-1-yl)-2-(4-(trifluoromethyl)phenyl)ethan-1-one
4-Trifluoromethylbenzyl chloride

Downstream Product

Methyl 4-(2-methoxy-2-oxoethyl)benzoate
Ethyl 4-(TRIFLUOROMEthyl)Phenyl Acetate
3-hydroxy-2-isobutyl-3-(4-(trifluoromethyl)benzyl)isoindolin-1-one
4-(Trifluoromethyl)benzaldehyde

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