Home > Organophosphorus Compounds> 2-(2-amino-6-oxo-3H-purin-9-yl)ethoxymethylphosphonic acid

2-(2-amino-6-oxo-3H-purin-9-yl)ethoxymethylphosphonic acid

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Origin: China

Cas No: 114088-58-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 114088-58-3 Formula: C8H12N5O5P Molecular Weight: 289.18500

Description

PMEG is an antiviral that has been tested to treat certain types of herpes in mice. GS-9191 and GS-9219 are PMEG pro-drugs.

Basic Info

Chemical Name	2-(2-amino-6-oxo-3H-purin-9-yl)ethoxymethylphosphonic acid
Synonyms	((2-(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)ethoxy)methyl)phosphonic acid; 9-(2-(phosphonomethoxy)ethyl)guanine; (2-(2-amino-6-oxo-1,6-dihydropurin-9-yl)ethoxy)methylphosphonic acid; 9-((2-Phosphonylmethoxy)ethyl)guanine; ((2-(2-amino-6-oxo-1H-purin-9(6H)-yl)ethoxy)methyl)phosphonic acid; PMEG; 5-(3-Hydroxy-2-phosphonomethoxypropylguanine); Phosphonic acid,((2-(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)ethoxy)methyl);
CAS No.	114088-58-3
Molecular Formula	C8H12N5O5P
Molecular Weight	289.18500
PSA	167.15000
LogP	-0.80400

Properties

Density	2.03g/cm3
Boiling Point	726.5ºC at 760mmHg
Flash Point	393.2ºC
Refractive Index	1.803
Vapor Pressure	3.75E-22mmHg at 25°C

Synthesis Route

9-[2-[(diisopropoxyphosphoryl)methoxy]ethyl]guanine→2-(2-amino-6-oxo-3H-purin-9-yl)ethoxymethylphosphonic acid
bromo(trimethyl)silane+5-amino-3-<2-(diethylphosphonomethoxy)ethyl>-3H-imidazo<4,5-d>pyrimidin-7-one→2-(2-amino-6-oxo-3H-purin-9-yl)ethoxymethylphosphonic acid
((2-(2-amino-6-chloro-9H-purin-9-yl)ethoxy)methyl)phosphonic acid→2-(2-amino-6-oxo-3H-purin-9-yl)ethoxymethylphosphonic acid

Precursor

((2-(2-amino-6-chloro-9H-purin-9-yl)ethoxy)methyl)phosphonic acid
bromo(trimethyl)silane
5-amino-3-<2-(diethylphosphonomethoxy)ethyl>-3H-imidazo<4,5-d>pyrimidin-7-one
9-[2-[(diisopropoxyphosphoryl)methoxy]ethyl]guanine

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