Home > Chiral Compounds> (1S,5R,6S)-Ethyl 5-(pentan-3-yl-oxy)-7-oxa-bicyclo[4.1.0]hept-3-ene-3-carboxylate

(1S,5R,6S)-Ethyl 5-(pentan-3-yl-oxy)-7-oxa-bicyclo[4.1.0]hept-3-ene-3-carboxylate

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Origin: China

Cas No: 204254-96-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
204254-96-6
Other Names:
(1S,5R,6S)-ethyl 5-(pentan-3-yloxy)-7-
MF:
C14H22O4
EINECS No.:
204254-96-6
Place of Origin:
Anhui, China
Type:
Agrochemical Intermediates, Dyestuff Intermediates, Flavor & Fragrance Intermediates
Purity:
99%
Brand Name:
GSK
Model Number:
204254-96-6
Application:
Chemical
Appearance:
White Endocardial pocket
Packing:
1kg/Alu bag or 25kg/Drum
Molecular Weight:
254.32g/mol
Grade:
Phamaceutical Grade
Shelf life:
Aluminum foil bag
Packaging&Delivery
Packaging Details
1kg/Alu bag or 25kg/Drum
Packing method :Woven bag or draft paper bag atteched polyethylene endometrium bag packing tightly or as buyer request
Port
Any mainly port in China
Lead Time:
Quantity(Kilograms) 1 - 25 >25
Est. Time(days) 3 To be negotiated

Property

CAS No.: 204254-96-6 Formula: C14H22O4 Molecular Weight: 254.32200

Description

An intermediate of Oseltamivir.

Basic Info

Chemical Name	(1S,5R,6S)-Ethyl 5-(pentan-3-yl-oxy)-7-oxa-bicyclo[4.1.0]hept-3-ene-3-carboxylate
Synonyms	ethyl(3R,4R,5S)-4,5-epoxy-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid; (1S,5R,6S)-5-(1-Ethyl-propoxy)-7-oxa-bicyclo[4.1.0]hept-3-ene-3-carboxylic acid ethyl ester; [1s-(1a,5b,6a)]-5-(1-ethylpropoxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic acid ethyl ester; ETHYL(3R,4S,5S)-4,5-EPOXY-3-(1-ETHYL-PROPOXY)-CYCLOHEX-1-ENE-1-CARBOXYLATE; 7-Oxabicyclo[4.1.0]hept-3-ene-3-carboxylic acid,5-(1-ethylpropoxy)-,ethyl ester,(1S,5R,6S); ETHYL(3R,4S,5S)-4,5-EPOXY-3-(1-ETHYL-PROPOXY)-CYCLOHEX-1-ENE-1-CARBOXYLATE(INTERMEDIATE OF OSELTAMIVIR PHOSPHATE ); Ethyl (1S,5R,6S)-5-(pentan-3-yl-oxy)-7-oxa-bicyclo[4.1.0]hept-3-ene-3-carboxylate; Ethyl (3R,4S,5S)-4,5-Epoxy-3-(1-ethylpropoxy)cyclohex-1-ene-1-carboxylate; EEC epoxide;
CAS No.	204254-96-6
Molecular Formula	C14H22O4
Molecular Weight	254.32200
PSA	48.06000
LogP	2.22080

Properties

Appearance & Physical State	White to off-white solid
Density	1.09g/cm3
Boiling Point	336.495ºC at 760 mmHg
Melting Point	56-57ºC
Flash Point	145.075ºC
Refractive Index	1.492
Vapor Pressure	0mmHg at 25°C

Synthesis Route

ethyl (3R,4R,5R)-3-(1-ethyl-propoxy)-4-hydroxy-5-methanesulfonyloxycyclohex-1-ene-1-carboxylate→(1S,5R,6S)-Ethyl 5-(pentan-3-yl-oxy)-7-oxa-bicyclo[4.1.0]hept-3-ene-3-carboxylate
ethyl (3aR,7R,7aR)-2,2-dimethyl-7-methanesulfonyloxy-3a,6,7,7a-tetrahydrobenzo[1,3]dioxole-5-carboxylate→(1S,5R,6S)-Ethyl 5-(pentan-3-yl-oxy)-7-oxa-bicyclo[4.1.0]hept-3-ene-3-carboxylate
ethyl 3,4-O-isopropylidene-5-O-(methansulfonyl)shikimate→(1S,5R,6S)-Ethyl 5-(pentan-3-yl-oxy)-7-oxa-bicyclo[4.1.0]hept-3-ene-3-carboxylate

Precursor

ethyl (3aR,7R,7aR)-2,2-dimethyl-7-methanesulfonyloxy-3a,6,7,7a-tetrahydrobenzo[1,3]dioxole-5-carboxylate
Quinic acid
ethyl 3,4-O-isopropylidene-5-O-methanesulfonyl quinate
ethyl (3R,4R,5R)-3-(1-ethyl-propoxy)-4-hydroxy-5-methanesulfonyloxycyclohex-1-ene-1-carboxylate

Downstream Product

(1R,5R,6R)-5-(1-Ethylpropoxy)-7-azabicyclo[4.1.0]hept-3-ene-3-carboxylic Acid Ethyl Ester
oseltamivir phosphate
oseltamivir
Ethyl(3R,4R,5S)-4-N-AcetaMido-5-azido-3- (1-ethylpropoxy)-1-cyclohexene-1-carboxylate

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