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(1S,3R,5Z,8ξ)-1,3-Bis{[dimethyl(2-methyl-2-propanyl)silyl]oxy}-9, 10-secocholesta-5,10-dien-25-ol

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Origin: China

Cas No: 140710-98-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 140710-98-1 Formula: C39H74O3Si2 Molecular Weight: 647.17400

Basic Info

Chemical Name	(1S,3R,5Z,8ξ)-1,3-Bis{[dimethyl(2-methyl-2-propanyl)silyl]oxy}-9, 10-secocholesta-5,10-dien-25-ol
Synonyms	MHED HYDROCHLORIDE; (1RS:2SR)-2-methylamino-1-(3-hydroxy-phenyl)-propanol-(1),hydrochloride; (1S),3(R)-bis<(tert-butyldimethylsilyl)oxy>-9,10-secocholesta-5(E),7(E),10(19)-trien-25-ol;
CAS No.	140710-98-1
Molecular Formula	C39H74O3Si2
Molecular Weight	647.17400
PSA	38.69000
LogP	11.84360

Synthesis Route

Methylmagnesium bromide+ethyl (1S),3(R)-bis<(tert-butyldimethylsilyl)oxy>-9,10-seco-26,27-bisnorcholesta-5(E),7(E),10(19)-trien-25-oate→(1S,3R,5Z,8ξ)-1,3-Bis{[dimethyl(2-methyl-2-propanyl)silyl]oxy}-9, 10-secocholesta-5,10-dien-25-ol
(6S)- and (6R)-SO2 adducts of 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-9,10-secoergosta-5(E),7(E),10(19),22(E)-tetraene→(1S,3R,5Z,8ξ)-1,3-Bis{[dimethyl(2-methyl-2-propanyl)silyl]oxy}-9, 10-secocholesta-5,10-dien-25-ol
(1S),3(R)-bis<(tert-butyldimethylsilyl)oxy>-20(S)-(hydroxymethyl)-9,10-secopregna-5(E),7(E),10(19)-triene→(1S,3R,5Z,8ξ)-1,3-Bis{[dimethyl(2-methyl-2-propanyl)silyl]oxy}-9, 10-secocholesta-5,10-dien-25-ol

Precursor

Methylmagnesium bromide
ethyl (1S),3(R)-bis<(tert-butyldimethylsilyl)oxy>-9,10-seco-26,27-bisnorcholesta-5(E),7(E),10(19)-trien-25-oate
(1S),3(R)-bis<(tert-butyldimethylsilyl)oxy>-20(S)-(hydroxymethyl)-9,10-secopregna-5(E),7(E),10(19)-triene
(6S)- and (6R)-SO2 adducts of 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-9,10-secoergosta-5(E),7(E),10(19),22(E)-tetraene

Downstream Product

calcitriol
5,6-trans-1alpha,25-Dihydroxyvitamin D3

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