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Picture of (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride

(1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride

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Origin: China

CasNo: 145307-34-2

specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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  • Products Specification
  • Description
  • Property

    CAS No.: 145307-34-2 Formula: C20H28ClNO3 Molecular Weight: 365.89400

    Description

    A-77636 is a synthetic drug which acts as a selective D1 receptor full agonist. It has nootropic, anorectic, rewarding and antiparkinsonian effects in animal studies, but its high potency and long duration of action causes D1 receptor downregulation and tachyphylaxis, and unlike other D1 full agonists such as SKF-82,958, it does not produce place preference in animals. A-77636 partially substituted for cocaine in animal studies, and has been suggested for use as a possible substitute drug in treating addiction, but it is better known for its use in studying the role of D1 receptors in the brain.

    Basic Info

    Chemical Name (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride
    Synonyms

    A-77636 hydrochloride hydrate;
    (1R,3S)-3-(1'-adamantyl)-1-aminomethyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride;

    CAS No. 145307-34-2
    Molecular Formula C20H28ClNO3
    Molecular Weight 365.89400
    PSA 75.71000
    LogP 4.75760

    Properties

    Boiling Point 515.3ºC at 760 mmHg
    Flash Point 265.5ºC
    Storage Condition -20ºC
    Vapor Pressure 3.06E-11mmHg at 25°C

    Synthesis Route

    (1S,3R)-3-(1'-adamantyl)-1-(aminomethyl)-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran(1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride
    1-(adamantan-1-yl)-2-(spiro[benzo[d][1,3]dioxole-2,1'-cyclohexan]-4-yl)ethan-1-one(1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride
    Oxirane, tricyclo[3.3.1.13,7]dec-1-yl-, (R)-(1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride

    Precursor

    1-(adamantan-1-yl)-2-(spiro[benzo[d][1,3]dioxole-2,1'-cyclohexan]-4-yl)ethan-1-one
    (1S,3R)-3-(1'-adamantyl)-1-(aminomethyl)-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran

    Oxirane, tricyclo[3.3.1.13,7]dec-1-yl-, (R)-

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