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Picture of (1R)-N-((1R)-1-Phenylethyl)-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine

(1R)-N-((1R)-1-Phenylethyl)-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine

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Origin: China

CasNo: 672314-45-3

specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
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    CAS No.: 672314-45-3 Formula: C23H41NOSi Molecular Weight: 375.66300

    Description

    Intermediate in the production of Rho kinase inhibitors and neurite outgrowth promoters.

    Basic Info

    Chemical Name (1R)-N-((1R)-1-Phenylethyl)-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine
    Synonyms

    (1S)-1-[4-({[Dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl)cycloh exyl]-N-[(1S)-1-phenylethyl]ethanamine;

    CAS No. 672314-45-3
    Molecular Formula C23H41NOSi
    Molecular Weight 375.66300
    PSA 21.26000
    LogP 6.94480

    Synthesis Route

    Methylmagnesium bromide+(R)-N-[(4'-tert-butyldimethylsilyloxymethyl-cyclohexyl)methylidene]-1-phenylethanamine(1R)-N-((1R)-1-Phenylethyl)-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine
    1,4-Cyclohexanedimethanol(1R)-N-((1R)-1-Phenylethyl)-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine
    (1R)-1-phenylethanamine(1R)-N-((1R)-1-Phenylethyl)-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine

    Precursor

    Methylmagnesium bromide
    (R)-N-[(4'-tert-butyldimethylsilyloxymethyl-cyclohexyl)methylidene]-1-phenylethanamine
    tert-butyldimethylsilyl chloride
    (1R)-1-phenylethanamine

    Downstream Product

    (R)-1-[4-(tert-Butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine
    tert-butyl N-[(1R)-1-[4-(pyridin-4-ylcarbamoyl)cyclohexyl]ethyl]carbamate
    (R)-N-Boc-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine

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