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1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE

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Origin: China

Cas No: 63-89-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 63-89-8 Formula: C40H80NO8P Molecular Weight: 734.03900

Description

Colfosceril palmitate (trade name Exosurf) is a drug used as a pulmonary surfactant. It is a drug that is used in surfactant deficient conditions such as IRDS in newborns.

Basic Info

Chemical Name	1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Synonyms	Colfosceril palmitate; Colfosceril;
CAS No.	63-89-8
Molecular Formula	C40H80NO8P
Molecular Weight	734.03900
PSA	121.00000
LogP	11.68200

Properties

Appearance & Physical State	White crystalline powder
Melting Point	229-229.5ºC
Stability	Stable. Incompatible with strong oxidizing agents.
Storage Condition	-20ºC

Safety Info

Safety Statements	S24/25
WGK Germany	3

Synthesis Route

choline alfoscerate+Palmitic acid→1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
2-(1',2'-dipalmitoyl-sn-glycero)-2-oxo-1,3,2-dioxaphospholane+trimethylamine→1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
2-Chloroethylphosphoryl Dichloride+1,2-dipalmitoyl-sn-glycerol→1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE

Precursor

choline alfoscerate
Palmitic acid
2-(1',2'-dipalmitoyl-sn-glycero)-2-oxo-1,3,2-dioxaphospholane
trimethylamine

Downstream Product

Palmitic acid
choline
L-α-glycerophosphorylcholine
1-Palmitoyl-sn-glycero-3-phosphocholine

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