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1-bromo-2-chloroethane

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Origin: China

Cas No: 107-04-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

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CAS No.: 107-04-0 Formula: C2H4BrCl Molecular Weight: 143.41000

Description

1-Bromo-2-chloroethane is a reagent used in the preparation of potent P-glycoprotein inhibitors carrying a polycyclic scaffold.

Basic Info

Chemical Name	1-bromo-2-chloroethane
Synonyms	Chlorobromoethane; 2-bromochloroethane; Ethane, 1-bromo-2-chloro-; CH2BrCH2Cl; s-Chlorobromoethane; 1-Brom-2-chlorethan; 2-Bromoethyl Chloride; bromo-2-chloroethane; ethylenbromchlorid; 1-bromo-2-chloroproethane; 1-Bromo-2-chloroethane; 1-bromo-2-chloro-ethane; wellno.436b; 1-chloro-2-bromoethane; 1-Bromo-2-chloroetha; 2-Chloroethyl Bromide; 1,2-Chlorobromoethane;
CAS No.	107-04-0
Molecular Formula	C2H4BrCl
Molecular Weight	143.41000
PSA	0.00000
LogP	1.62010

Properties

Appearance & Physical State	Clear colorless to slightly yellow liquid
Density	1.723
Boiling Point	106-107ºC
Melting Point	-17ºC
Flash Point	9.5ºC
Refractive Index	1.49-1.492
Water Solubility	7 g/L (20 ºC)
Stability	Stable under normal temperatures and pressures.
Storage Condition	Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.
Vapor Pressure	32.6mmHg at 25°C

Safety Info

RTECS	KH6500000
Hazard Class	6.1
Safety Statements	S28-S36/37/39-S38-S45
HS Code	29034980
WGK Germany	3
Packing Group	III
RIDADR	UN 2810
Risk Statements	R23/25; R36/37/38; R68
Hazard Codes	T

Synthesis Route

aluminium trichloride+chloroethane→Bromoethane+1,2-Dichloroethane
magnesium,ethynylbenzene,bromide+Diethyl ether→1-bromo-2-chloroethane+Phenylacetylene
Bromoethylphosphonic acid bis(bromoethyl) ester+phosphorus pentachloride→1-bromo-2-dichlorophosphorylethane+1-bromo-2-chloroethane

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Packed	OV-1	100.	716.	isothermal
Packed	OV-1	125.	723.	isothermal
Packed	OV-1	75.	708.	isothermal
Packed	Squalane	27.	681.	isothermal
Packed	Squalane	49.	688.	isothermal

Precursor

1,2-Dichloroethane
2-chloroethanol
bromoacetamide
ethene

Downstream Product

dimethyl 1-(2-chloroethyl)cyclohexane-1,4-dicarboxylate
dimethyl 1-(2'-chloroethyl)cyclohexane-1,3-dicarboxylate
Dimethyl bicyclo[3.2.1]octane-1,5-dicarboxylate
5-(2-chloroethoxy)-2,3-dihydroinden-1-one

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