Home > Heterocyclic Compounds> 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine

1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine

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Origin: China

Cas No: 22345-47-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 22345-47-7 Formula: C22H26N2O4 Molecular Weight: 382.45300

Basic Info

Chemical Name	1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine
Synonyms	7,8-dimethoxy-1-(3,4-dimethoxyphenyl)-5-ethyl-4-methyl-5H-2,3-benzodiazepine; Grandaxin; 1-(3,4-dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine; 1-(3,4-dimethoxyphenyl)-7,8-dimethoxy-5-ethyl-4-methyl-5H-2,3-benzodiazepine; 7,8-Dimethoxy-1-(3,4-dimethoxyphenyl)-5-ethyl-4-methyl-5H-2,3-benzodiazepine,EGYT 341,Seriel; 5-aethyl-1-(3,4-dimethoxyphenyl)-7,8-dimethoxy-4-methyl-5H-benzodiazepin; tofizopam; Egyt 341; EINECS 244-922-3; Tofisopamum [INN-Latin]; Seriel; tofisopam; Tofisopam [INN:DCF:JAN]; Emandaxin;
CAS No.	22345-47-7
Molecular Formula	C22H26N2O4
Molecular Weight	382.45300
PSA	61.64000
LogP	3.31270

Properties

Appearance & Physical State	white solid
Density	1.15g/cm3
Boiling Point	479ºC at 760 mmHg
Melting Point	155-159ºC
Flash Point	195.2ºC
Refractive Index	1.558
Vapor Pressure	7.13E-09mmHg at 25°C

Safety Info

RTECS	DE9540000
Hazard Class	6.1(b)
Safety Statements	60-61
WGK Germany	2
Packing Group	III
RIDADR	UN 3077
Risk Statements	R22; R50
Hazard Codes	Xn; N

Synthesis Route

3-[2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl]pentan-2-one→1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine
(-)-Tofisopam→1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine
1-(3,4-dimethoxyphenyl)-4-ethyl-6,7-dimethoxy-3-methylisochromenylium chloride hydrochloride→1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Capillary	OV-1	-	3055.	custom temperature program

Precursor

(-)-Tofisopam
1-(3,4-dimethoxyphenyl)-6,7-dimethoxy-4-ethyl-3-methylisochroman
3,4-dimethoxybenzaldehyde
3-[2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl]pentan-2-one

Downstream Product

(-)-Tofisopam
1-[1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-2,3-benzodiazepin-3-yl]ethanone
6-bromo-5-chloro-3-(2-oxo-propyl)-3H-benzooxazol-2-one
(5R)-1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine

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