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1-(2,5-difluorophenyl)ethanone

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Origin: China

Cas No: 1979-36-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 1979-36-8 Formula: C8H6F2O Molecular Weight: 156.12900

Description

2',5'-Difluoroacetophenone is used in the synthesis of pyrazole compounds as inhibitors of dipeptidyl peptidases. These compounds have been shown to produce anti-hyperglycemic effects.

Basic Info

Chemical Name	1-(2,5-difluorophenyl)ethanone
Synonyms	fr df bv1; 2′,5′-Difluoroacetophenone; 1-acetyl-2,5-difluorobenzene; 1-(2,5-Difluorophenyl)ethanone; 2,5-Difluoroacetophenone;
CAS No.	1979-36-8
Molecular Formula	C8H6F2O
Molecular Weight	156.12900
PSA	17.07000
LogP	2.16740

Properties

Appearance & Physical State	Light brown - colorless liquid.
Density	1.233
Boiling Point	190.7ºC at 760 mmHg
Flash Point	70.3ºC
Refractive Index	1.4855-1.4895
Stability	Stable at room temperature in closed containers under normal storage and handling conditions.
Storage Condition	Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Vapor Pressure	1.06E-05mmHg at 25°C

Safety Info

Safety Statements	S26-S37/39
HS Code	2914700090
WGK Germany	3
Risk Statements	R36/37/38
Hazard Codes	Xi
Signal Word	Warning
Hazard Declaration	H315; H319; H335
Symbol	GHS07
Caution Statement	P261; P305 + P351 + P338

Synthesis Route

acetophenone→2'-Fluoroacetophenone+1-(3,3,6,6-tetrafluorocyclohexa-1,4-dien-1-yl)ethanone
1,4-difluorobenzene+acetyl chloride→1-(2,5-difluorophenyl)ethanone

Precursor

acetyl chloride
acetophenone
1,4-difluorobenzene

Downstream Product

3-fluorobenzoic acid
2-Bromo-2',5'-difluoroacetophenone
1-(2,5-difluorophenyl)-4,4,4-trifluorobutane-1,3-dione
3-(2,5-difluorophenyl)-3-oxopropanenitrile

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