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(+)-Quisqualic Acid

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начало: Китай

Кас Но: 52809-07-1

Спецификация: 99%наименьший

минимальный объем заказа: 1 /kg

снабженческая способность: 50 mt/month

опережающий период: OEM 7 дней, пятно 3 дня

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CAS No.: 52809-07-1 Formula: C5H7N3O5 Molecular Weight: 189.12600

Description

Quisqualic acid is an agonist of the AMPA, kainate, and group I metabotropic glutamate receptors, and one of the most potent AMPA receptor agonists known. It causes excitotoxicity and is used in neuroscience to selectively destroy neurons in the brain or spinal cord. Quisqualic acid occurs naturally in the seeds of Quisqualis species.[α] 20D = +17 (6M HCl); Research conducted by the USDA Agricultural Research Service, has demonstrated quisqualic acid is also present within the flower petals of zonal geranium (Pelargonium x hortorum) and is responsible for causing rigid paralysis of the Japanese beetle. Quisqualic acid is thought to mimic L-glutamic acid, which is a neurotransmitter in the insect neuromuscular junction and mammalian central nervous system.

Basic Info

Chemical Name	(+)-Quisqualic Acid
Synonyms	L-Quisqualic acid,(L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoicacid;
CAS No.	52809-07-1
Molecular Formula	C5H7N3O5
Molecular Weight	189.12600
PSA	131.32000
LogP	-1.75820

Properties

Appearance & Physical State	white powder
Density	1.679g/cm3
Melting Point	185-187ºC dec.
Refractive Index	1.571
Stability	Stable. Incompatible with strong oxidizing agents.
Storage Condition	2-8ºC

Safety Info

Safety Statements	S26; S36
HS Code	2934999090
Risk Statements	R20/21/22
Hazard Codes	Xn
Symbol	GHS07
Caution Statement	P280
Signal Word	Warning
Hazard Declaration	H302; H312; H332

Synthesis Route

O-acetyl-L-serine+1,2,4-OXADIAZOLIDINE-3,5-DIONE→(+)-Quisqualic Acid
L-Cysteine+1,2,4-OXADIAZOLIDINE-3,5-DIONE→(+)-Quisqualic Acid
tert-butyl (S)-(2-((ethoxycarbonyl)carbamoyl)-5-oxoisoxazolidin-4-yl)carbamate→(+)-Quisqualic Acid

Precursor

O-acetyl-L-serine
1,2,4-OXADIAZOLIDINE-3,5-DIONE
L-serine
tert-butyl (S)-(2-((ethoxycarbonyl)carbamoyl)-5-oxoisoxazolidin-4-yl)carbamate

Downstream Product

Albizziin

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