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(+)-Quisqualic Acid

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Origin: China

CasNo: 52809-07-1

specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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  • Products Specification
  • Description
  • Property

    CAS No.: 52809-07-1 Formula: C5H7N3O5 Molecular Weight: 189.12600

    Description

    Quisqualic acid is an agonist of the AMPA, kainate, and group I metabotropic glutamate receptors, and one of the most potent AMPA receptor agonists known. It causes excitotoxicity and is used in neuroscience to selectively destroy neurons in the brain or spinal cord. Quisqualic acid occurs naturally in the seeds of Quisqualis species.[α] 20D = +17 (6M HCl); Research conducted by the USDA Agricultural Research Service, has demonstrated quisqualic acid is also present within the flower petals of zonal geranium (Pelargonium x hortorum) and is responsible for causing rigid paralysis of the Japanese beetle. Quisqualic acid is thought to mimic L-glutamic acid, which is a neurotransmitter in the insect neuromuscular junction and mammalian central nervous system.

    Basic Info

    Chemical Name (+)-Quisqualic Acid
    Synonyms

    L-Quisqualic acid,(L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoicacid;

    CAS No. 52809-07-1
    Molecular Formula C5H7N3O5
    Molecular Weight 189.12600
    PSA 131.32000
    LogP -1.75820

    Properties

    Appearance & Physical State white powder
    Density 1.679g/cm3
    Melting Point 185-187ºC dec.
    Refractive Index 1.571
    Stability Stable. Incompatible with strong oxidizing agents.
    Storage Condition 2-8ºC

    Safety Info

    Safety Statements S26; S36
    HS Code 2934999090
    Risk Statements R20/21/22
    Hazard Codes Xn
    Symbol GHS07
    Caution Statement P280
    Signal Word Warning
    Hazard Declaration H302; H312; H332

    Synthesis Route

    O-acetyl-L-serine+1,2,4-OXADIAZOLIDINE-3,5-DIONE(+)-Quisqualic Acid
    L-Cysteine+1,2,4-OXADIAZOLIDINE-3,5-DIONE(+)-Quisqualic Acid
    tert-butyl (S)-(2-((ethoxycarbonyl)carbamoyl)-5-oxoisoxazolidin-4-yl)carbamate(+)-Quisqualic Acid

    Precursor

    O-acetyl-L-serine
    1,2,4-OXADIAZOLIDINE-3,5-DIONE
    L-serine
    tert-butyl (S)-(2-((ethoxycarbonyl)carbamoyl)-5-oxoisoxazolidin-4-yl)carbamate

    Downstream Product

    Albizziin

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