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β-propiolactone

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Origin: China

Cas No: 57-57-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 57-57-8 Formula: C3H4O2 Molecular Weight: 72.06270

    Description

    β-Propiolactone is an organic compound of the lactone family, with a four-membered ring. It is a clear, colorless liquid with a slightly sweet odor, highly soluble in water and miscible with ethanol, acetone, diethyl ether and chloroform. The word propiolactone usually refers to this compound, although it may also refer to α-propiolactone.
    β-Propiolactone is "reasonably anticipated to be a human carcinogen" (IARC, 1999). It is one of 13 "OSHA-regulated carcinogens," chemicals regarded occupational carcinogens by the Occupational Safety and Health Administration, despite not having an established permissible exposure limit. It was once widely used in the manufacture of acrylic acid and its esters, but its use has been mostly phased out in favor of safer and less expensive alternatives. β-Propiolactone is a sterilizing and sporicidal agent, and has been used to sterilize blood plasma, vaccines, tissue grafts, surgical instruments, and enzymes. The principal current use of propiolactone is an intermediate in the synthesis of other chemical compounds.
    β-Propiolactone will slowly react with water and hydrolyze to produce 3-hydroxypropionic acid (hydracryclic acid).

    Basic Info

    Chemical Name β-propiolactone
    Synonyms

    beta-propiolactone;
    2-Oxetanone;
    oxetan-2-one;

    CAS No. 57-57-8
    Molecular Formula C3H4O2
    Molecular Weight 72.06270
    PSA 26.30000
    LogP -0.06670

    Properties

    Appearance & Physical State A colorless liquid with a slightly sweetish, pungent odor.
    Density 1.146
    Boiling Point 162ºC
    Melting Point -33ºC
    Flash Point 70ºC
    Refractive Index 1.412-1.414
    Water Solubility 37 g/100 mL
    Stability Stable when stored at +5ºC in glass containers.
    Storage Condition 2-8ºC

    Safety Info

    RTECS RQ7350000
    Hazard Class 6.1
    Safety Statements S45-S53
    HS Code 2932209090
    WGK Germany 3
    Packing Group I
    RIDADR UN 3382
    Risk Statements R26; R36/38; R45
    Hazard Codes T+

    Synthesis Route

    L-glutamic acidmaleimide+succinimide
    oxirane+carbon monoxideβ-propiolactone
    Cyclopropanoneβ-propiolactone

    Precursor

    oxirane
    3-Bromopropionic acid
    Cyclopropanone
    carbon monoxide

    Downstream Product

    3-(3-diethoxyphosphoryl-propionyloxy)-propionic acid ethyl ester
    TRIETHYL 3-PHOSPHONOPROPIONATE
    3-(2-Benzothiazolylthio)propionic Acid
    8-chloro-3,5-dihydro-2H-1,5-benzothiazepin-4-one

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