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(-)-β-HYDRASTINE

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Origin: China

Cas No: 118-08-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 118-08-1 Formula: C21H21NO6 Molecular Weight: 383.39500

Description

Hydrastine is an alkaloid which was discovered in 1851 by Alfred P. Durand. Hydrolysis of hydrastine yields hydrastinine, which was patented by Bayer as a haemostatic drug during the 1910s. It is present in Hydrastis canadensis (thus the name) and other plants of the Ranunculaceae family.

Basic Info

Chemical Name	(-)-β-HYDRASTINE
Synonyms	Hydrastine (10 mg); HYDRASTINE; (-)-Beta-Hydrastine; (-)-B-HYDIASTINE; HYDRASTINE,(-)-B; quinolin-5-yl); Hydrastinebase; 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [S-(R,S)]-; l-hydrastine;
CAS No.	118-08-1
Molecular Formula	C21H21NO6
Molecular Weight	383.39500
PSA	66.46000
LogP	2.81110

Properties

Density	1.339g/cm3
Boiling Point	548.8ºC at 760mmHg
Melting Point	132ºC
Flash Point	285.7ºC
Refractive Index	1.614
Storage Condition	-20ºC
Vapor Pressure	4.28E-12mmHg at 25°C

Safety Info

RTECS	MU6030000
Hazard Class	6.1(b)
Safety Statements	36
Packing Group	III
WGK Germany	3
RIDADR	UN 1544
Risk Statements	R20/21/22
Hazard Codes	Xn

Synthesis Route

5-((R)-4,5-Dimethoxy-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-6-methyl-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium→6,7-dimethoxy-3H-2-benzofuran-1-one+(-)-β-HYDRASTINE
narcotoline-8-(1-phenyl-1H-5-tetrazolyl) ether→(-)-β-HYDRASTINE
(S)-3-((R)-6,7-dihydroxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-yl)-6,7-dimethoxy-3H-isobenzofuran-1-one+bromochloromethane→(-)-β-HYDRASTINE

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Packed	OV-1	-	2985.	temperature ramp
Other	Methyl Silicone	-	2988.	custom temperature program

Precursor

diazomethane
bromochloromethane
narcotoline-8-(1-phenyl-1H-5-tetrazolyl) ether
(S)-3-((R)-6,7-dihydroxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-yl)-6,7-dimethoxy-3H-isobenzofuran-1-one

Downstream Product

Nicotinic acid
formic acid
3,4-dihydroxybenzoic acid
6,7-dimethoxy-3H-2-benzofuran-1-one

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