Welcome to GlobalChemMall

Picture of (+)-calanolide A

(+)-calanolide A

Get Latest Price >

FOB Price contact us for price

Origin: China

Cas No: 142632-32-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods


Payment Terms:

Inquiry now

* Send an Inquiry to us

Add to wishlist

* Name your price
* Start order doesn't mean buying now

  • Products Specification
  • Product Description
  • Property

    CAS No.: 142632-32-4 Formula: C22H26O5 Molecular Weight: 370.43900


    Calanolide A is an experimental non-nucleoside reverse transcriptase inhibitor (NNRTI) first acquired from the Calophyllum lanigerum, variety austrocoriaceum, trees in the Malaysian state of Sarawak by botanist John Burley in 1987. The U.S. National Cancer Institute tested calanolide A as a possible cancer treatment, but had no effect. It was later found to have potent anti-HIV activity. On return trip to Malaysia, it was found that all of the austrocoriaceum variety tree species of Calophyllum lanigerum had been cut down most likely for fuel and building material in the swamp forest near Lundu where the first tree samples were taken; however, a few existing species were eventually located in the Singapore Botanic Garden. Since the plant source is relatively rare, a total synthesis was developed in 1996. The form in current use is formulated for oral administration and produced by Sarawak MediChem in Lemont, Illinois.
    Calanolide A is unique among NNRTIs in that it may bind two distinct sites in reverse transcriptase.

    Basic Info

    Chemical Name (+)-calanolide A


    CAS No. 142632-32-4
    Molecular Formula C22H26O5
    Molecular Weight 370.43900
    PSA 68.90000
    LogP 4.38010


    Density 1.181g/cm3
    Boiling Point 514.8ºC at 760mmHg
    Flash Point 177.2ºC
    Refractive Index 1.558
    Vapor Pressure 2E-11mmHg at 25°C

    Synthesis Route

    HI-D86(+)-Calanolide B+(+)-calanolide A
    (2R,3R,4S)-2,3,10,10-tetramethyl-6-oxo-8-propyl-3,4-dihydro-2H,6H,10H-dipyrano[2,3-f:2',3'-h]chromen-4-yl 2-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)acetate(+)-calanolide A
    HI-D86(+)-calanolide A


    (2R,3R,4S)-2,3,10,10-tetramethyl-6-oxo-8-propyl-3,4-dihydro-2H,6H,10H-dipyrano[2,3-f:2',3'-h]chromen-4-yl 2-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)acetate

Hot tags: (+)-calanolide a, China, manufacturers, suppliers, factory, wholesale, low price, high quality