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(-)-anisomycin

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Origin: China

CasNo: 22862-76-6

specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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  • Products Specification
  • Description
  • Quick Details

    CAS No.:
    22862-76-6
    Other Names:
    Anisomycin
    MF:
    C14H19NO4
    EINECS No.:
    245-269-7
    Place of Origin:
    china
    Purity:
    98%, >98%
    Classification:
    General Reagents
    Brand Name:
    Richest
    Model Number:
    Richest

    Packaging&Delivery

    Packaging Details
    1kg/bag,25kg/bag,25kg/drum or customer's request
    Port
    shanghai
    Lead Time:
    Quantity(Kilograms)1 - 25>25
    Est. Time(days)3To be negotiated
  • Property

    CAS No.: 22862-76-6 Formula: C14H19NO4 Molecular Weight: 265.30500

    Description

    Anisomycin, also known as flagecidin, is an antibiotic produced by Streptomyces griseolus which inhibits eukaryotic protein synthesis. Partial inhibition of DNA synthesis occurs at anisomycin concentrations that effect 95% inhibition of protein synthesis. Anisomycin can activate stress-activated protein kinases, MAP kinase and other signal transduction pathways.
    Anisomycin is inactive against bacteria.

    Basic Info

    Chemical Name (-)-anisomycin
    Synonyms

    ANISOMYCIN FROM STREPTOMYCES GRISEOLUS;
    antibioticpa-106;
    Anisomycin,(2R,3S,4S)-2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol3-acetate;
    FLAGECIDIN;
    ANISOMYCIN,STREPTOMYCES GRISEOLUS;
    2-p-methoxyphenylmethyl-3-acetoxy-4-hydroxypyrrolidine;
    (2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol 3-Acetate;

    CAS No. 22862-76-6
    Molecular Formula C14H19NO4
    Molecular Weight 265.30500
    PSA 67.79000
    LogP 0.83090

    Properties

    Appearance & Physical State White crystalline solid
    Density 1.21 g/cm3
    Boiling Point 398.7ºC at 760 mmHg
    Melting Point 140-141ºC
    Flash Point 194.9ºC
    Stability Stable. Incompatible with strong oxidizing agents.
    Storage Condition 2-8ºC
    Vapor Pressure 0mmHg at 25°C

    Safety Info

    Hazard Class 6.1(b)
    Safety Statements 45-36-26
    HS Code 2933990090
    Packing Group III
    RIDADR UN 3462 6
    Risk Statements R25
    Hazard Codes T

    Synthesis Route

    (2R,3S,4S)-3-acetoxy-N-(benzyloxycarbonyl)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidine(-)-anisomycin
    (2R,3S,4S)-3-Acetoxy-1-(tert-butoxycarbonyl)-4-(tert-butyldimethylsilyloxy)-2-(4-methoxybenzyl)pyrrolidine(-)-anisomycin
    (4R,5S,6S)-5-(tert-butyldimethylsilyloxy)-4-(4-methoxybenzyl)-2-phenyl-6-vinyl-5,6-dihydro-4H-1,3-oxazine(-)-anisomycin

    Precursor

    (2R,3S,4S)-3-Acetoxy-1-(tert-butoxycarbonyl)-4-(tert-butyldimethylsilyloxy)-2-(4-methoxybenzyl)pyrrolidine
    (4R,5S,6S)-5-(tert-butyldimethylsilyloxy)-4-(4-methoxybenzyl)-2-phenyl-6-vinyl-5,6-dihydro-4H-1,3-oxazine
    (4R,5S,6S)-4-(4-methoxybenzyl)-2-phenyl-6-vinyl-5,6-dihydro-4H-1,3-oxazin-5-ol
    (2R,3S,4S)-3-acetoxy-N-(benzyloxycarbonyl)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidine

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