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2-methoxy-17β-estradiol

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Origin: China

Cas No: 362-07-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
152-43-2
Other Names:
Quinestrol
MF:
C25H32O2
EINECS No.:
362-07-2
Place of Origin:
Shandong, China
Type:
Pharmaceutical Intermediates, Syntheses Material Intermediates, 99.0%min
Purity:
99.0%min
Brand Name:
ench
Model Number:
ench-152-43-2
Application:
Pharm Intermediates, Fine Chemical Intermediate
Appearance:
off-white Powder, off-white Powder
Product Name:
Quinestrol
Grade:
enterprise grade
Shelf life:
2 Years
melting point:
107-108°
MW::
364.52
density:
n/a
Boiling point:
n/a
Packaging&Delivery
Packaging Details
1kg / bag, aluminum foil bag, 25kg / barrel, or as your demand.
Port
China main ports

Property

CAS No.: 362-07-2 Formula: C19H26O3 Molecular Weight: 302.40800

Description

2-Methoxyestradiol (2-ME2) is a natural metabolite of estradiol. As an experimental drug candidate, it is being developed under the tradename of Panzem. It prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis), hence it is an angiogenesis inhibitor.
It also acts as a vasodilator.; 2-ME2 is derived from estradiol, although it binds poorly (2000-fold lower activational potency) to known estrogen receptors. However, 2-ME2 retains activity as a high-affinity agonist of the GPER (GPR30).
It induces apoptosis in some cancer cell lines.
It has undergone Phase 1 clinical trials against breast cancer.; A phase II trial of 18 advanced ovarian cancer patients reported encouraging results in Oct 2007.
Preclinical models also suggest that 2-ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis. Several studies have been conducted showing 2-ME2 is a microtubule-inhibitor and effective against prostate cancer in rodents.; As of 2015, all clinical development of 2-ME2 has been suspended or discontinued.

Basic Info

Chemical Name	2-methoxy-17β-estradiol
Synonyms	2-Methoxyestradiol; 2-Methoxy-β-estradiol; 2-methoxy-17beta-estradiol; 2-Methoxy 17β-Estradiol;
CAS No.	362-07-2
Molecular Formula	C19H26O3
Molecular Weight	302.40800
PSA	49.69000
LogP	3.61780

Properties

Appearance & Physical State	Off-white solid
Density	1.178g/cm3
Boiling Point	464.4ºC at 760mmHg
Melting Point	188-190ºC
Flash Point	234.7ºC
Refractive Index	1.586
Storage Condition	-20ºC

Safety Info

RTECS	KG7537500
Safety Statements	S22; S26; S36/37/39; S45; S53; S36
WGK Germany	3
RIDADR	UN 3077 9/PG 3
Risk Statements	R23/24/25
Hazard Codes	T
Caution Statement	P201; P261; P273; P280; P301 + P310; P305 + P351 + P338
Signal Word	Danger
Symbol	GHS06, GHS08, GHS09
Hazard Declaration	H301 + H311 + H331; H315; H319; H335; H350; H360; H372; H410

Synthesis Route

(8R,9S,13S,14S,17S)-2-methoxy-3,17-bis(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene→2-methoxy-17β-estradiol
3-Benzyloxy-2-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol→2-methoxy-17β-estradiol
2-methoxyestrone→2-methoxy-17β-estradiol

Precursor

3-Benzyloxy-2-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol
(8R,9S,13S,14S,17S)-3-hydroxy-2-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl acetate
2-methoxyestrone
(8R,9S,13S,14S,17S)-2-methoxy-3,17-bis(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene

Downstream Product

2-methoxyestrone
2-hydroxy-17β-estradiol

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