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17β-estradiol 3-benzoate

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Origin: China

Cas No: 50-50-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 50-50-0 Formula: C25H28O3 Molecular Weight: 376.48800

Description

Estradiol is the major estrogen secreted by the premenopausal ovary. Estradiol benzoate is an estradiol analog which contains a benzyl ester at the C-3 position. Estradiol benzoate is useful in the treatment of lesions produced by diminution of bodily production of estrogens.

Basic Info

Chemical Name	17β-estradiol 3-benzoate
Synonyms	ESTON-B; Solestro; β-Estradiol 3-benzoate; ODB; MEE; Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-benzoate; folone; Estradiol benzoate; EBZ; Graafina; 17beta-estradiol 3-benzoate; Estradiolbenzoate; diogynb;
CAS No.	50-50-0
Molecular Formula	C25H28O3
Molecular Weight	376.48800
PSA	46.53000
LogP	5.12280

Properties

Density	1.185g/cm3
Boiling Point	531.2ºC at 760mmHg
Melting Point	191-198ºC
Flash Point	212ºC
Refractive Index	1.604

Safety Info

RTECS	KG4050000
Safety Statements	S53-S22-S36/37/39-S45
WGK Germany	3
Risk Statements	R60; R61; R40
Hazard Codes	T

Synthesis Route

(13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl) benzoate→17β-estradiol 3-benzoate
17β-estradiol+Benzoyl Trifluoromethanesulfonate→[(8R,9S,13S,14S,17S)-3-benzoyloxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] benzoate+17β-estradiol 3-benzoate
(13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl) benzoate→17β-estradiol+17β-estradiol 3-benzoate

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Implant	TDLo - Lowest published toxic dose	Rodent - rat	25 mg/kg	1.Tumorigenic-neoplastic by RTECS criteria 2.Endocrine-tumors 3.Skin and Appendages-tumors
Subcutaneous	TDLo - Lowest published toxic dose	Rodent - mouse	24 mg/kg/36W-I	1.Tumorigenic-Carcinogenic by RTECS criteria 2.Blood-leukemia 3.Skin and Appendages-tumors
Parenteral	TDLo - Lowest published toxic dose	Rodent - mouse	38 mg/kg/57W-I	1.Tumorigenic-equivocal tumorigenic agent by RTECS criteria 2.Skin and Appendages-tumors 3.Tumorigenic-tumor types after systemic administration not seen spontaneously