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17β-estradiol

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Origin: China

Cas No: 50-28-2

Specification: 99%min

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 50-28-2 Formula: C18H24O2 Molecular Weight: 272.38200

    Description

    Estradiol is the major estrogen secreted by the premenopausal ovary.

    Basic Info

    Chemical Name 17β-estradiol
    Synonyms

    17-Beta-Estradiol;
    17Beta-Estradiol;
    Estra-1,3,5(10)-triene-3,17-diol(17b)-;
    Estra-1,3,5(10)-triene-3,17-diol (17β)-;

    CAS No. 50-28-2
    Molecular Formula C18H24O2
    Molecular Weight 272.38200
    PSA 40.46000
    LogP 3.60920

    Properties

    Appearance & Physical State white to off-white crystalline powder
    Density 1.17g/cm3
    Boiling Point 445.9ºC at 760mmHg
    Melting Point 173ºC
    Flash Point 209.6ºC
    Refractive Index 1.599
    Stability Stable. Incompatible with strong oxidizing agents.
    Storage Condition 2-8ºC

    Safety Info

    Hazard Class 6.1
    Safety Statements S53-S45
    Packing Group III
    Risk Statements R45
    Hazard Codes T
    Caution Statement P201; P263; P281; P308 + P313
    Symbol GHS08
    Hazard Declaration H351; H360Fd; H362
    Signal Word Danger

    Synthesis Route

    (8R,9S,13S,14S)-2-bromo-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol+Sodium methoxide→17β-estradiol+2-methoxy-17β-estradiol
    2-Iodoestradiol→17β-estradiol+2-methoxy-17β-estradiol
    (8R,9S,13S,14S)-2-bromo-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol→17β-estradiol+2-methoxy-17β-estradiol

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Subcutaneous LD - Lethal dose Rodent - rat >300 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Subcutaneous TDLo - Lowest published toxic dose Rodent - rat 4200 ug/kg/12W-I 1.Blood-changes in erythrocyte (RBC) count
    2.Nutritional and Gross Metabolic-weight loss or decreased weight gain
    3.Related to Chronic Data-changes in uterine weight
    Intraperitoneal TDLo - Lowest published toxic dose Rodent - rat 1400 mg/kg/13W-I 1.Tumorigenic-equivocal tumorigenic agent by RTECS criteria
    2.Endocrine-tumors

    Precursor

    estradiol-17β 3-propargyl ether
    boldenone
    ESTRONE ACETATE
    estrone

    Downstream Product

    4-hydroxy-17β-estradiol
    2-hydroxy-17β-estradiol
    Prenortestosterone
    [(8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] undecanoate

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