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zearalenone

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Origin: China

Cas No: 17924-92-4

Specification: 99%min

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 17924-92-4 Formula: C18H22O5 Molecular Weight: 318.36400

    Description

    Zearalenone (ZEN), also known as RAL and F-2 mycotoxin, is a potent estrogenic metabolite produced by some Fusarium and Gibberella species. Particularly is produced by Fusarium graminearum, Fusarium culmorum, Fusarium cerealis, Fusarium equiseti, Fusarium verticillioides, and Fusarium incarnatum; Several Fusarium species produce toxic substances of considerable concern to livestock and poultry producers, namely deoxynivalenol, T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS) and zearalenone. Zearalenone is the primary toxin, causing infertility, abortion or other breeding problems, especially in swine.
    Zearalenone is heat-stable and is found worldwide in a number of cereal crops, such as maize, barley, oats, wheat, rice, and sorghum.
    In addition to its actions on the classical estrogen receptors, zearalenone has been found to act as an agonist of the GPER (GPR30).

    Basic Info

    Chemical Name zearalenone
    Synonyms

    (3S,11E)-3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione;
    Zearalenone;

    CAS No. 17924-92-4
    Molecular Formula C18H22O5
    Molecular Weight 318.36400
    PSA 83.83000
    LogP 3.57960

    Properties

    Appearance & Physical State Crystalline Solid
    Density 1.168 g/cm3
    Boiling Point 600.4ºC at 760 mmHg
    Melting Point 164-165ºC
    Flash Point 219.5ºC
    Refractive Index 1.539
    Storage Condition -20ºC
    Vapor Pressure 0mmHg at 25°C

    Safety Info

    RTECS DM2550000
    Hazard Class 4.1
    Safety Statements S26-S36/37/39-S45
    Packing Group II; III
    WGK Germany 3
    RIDADR UN 3261
    Risk Statements R34; R62; R63
    Hazard Codes C

    Synthesis Route

    2,4-Dimethoxy-zearalenonezearalenone
    (S)-2,4-bis<(2-methoxyethoxy)methyl>zearalenonezearalenone
    (2R)-pent-4-en-2-olzearalenone

    Precursor

    (S)-2,4-bis<(2-methoxyethoxy)methyl>zearalenone
    5-HEXYN-1-OL
    Methyl 2,4-dihydroxybenzoate
    2,4-Dimethoxy-zearalenone

    Downstream Product

    (2E)-15-hydroxy-11-methyl-17-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-12-oxabicyclo[12.4.0]octadeca-1(18),2,14,16-tetraene-7,13-dione
    (S)-Zearalanone
    (7R,11S)-7,15,17-trihydroxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),15,17-trien-13-one
    (2E,7S,11S)-7,15,17-trihydroxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(18),2,14,16-tetraen-13-one

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