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Yohimbine

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Origem: China

Cas No: 146-48-5

Especificação: 99%Min

Quantidade de ordem min: 1 /kg

Capacidade de fornecimento: 50 mt/month

Tempo de espera: 7 dias para OEM, 3 dias para produtos prontos

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CAS No.: 146-48-5 Formula: C21H26N2O3 Molecular Weight: 354.44300

Description

Yohimbine is an indole alkaloid derived from the bark of the Pausinystalia yohimbe tree in Central Africa. It is a veterinary drug used to reverse sedation in dogs and deer. Yohimbine has been studied as a potential treatment for erectile dysfunction but there is insufficient evidence to rate its effectiveness. Extracts from yohimbe have been marketed as dietary supplements for improving sexual function.

Basic Info

Chemical Name	Yohimbine
Synonyms	APHRODINE; Yohimex; Yohimbin; Quebrachine; Aphrodyne; Quebrachin; Corynine; Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16α,17α)-; Yocon; Aphrosol; Yohimbine free base; methyl (1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate;
CAS No.	146-48-5
Molecular Formula	C21H26N2O3
Molecular Weight	354.44300
PSA	65.56000
LogP	2.58500

Properties

Density	1.31 g/cm3
Boiling Point	543ºC at 760 mmHg
Melting Point	231-233 °C(lit.); 241 °C
Flash Point	282.2ºC
Refractive Index	1.66
Vapor Pressure	1.27E-12mmHg at 25°C

Safety Info

RTECS	ZG1000000
Hazard Class	6.1(a)
Safety Statements	27-36/37/39-45
Packing Group	II
RIDADR	UN 1544
Risk Statements	R23/24/25
Hazard Codes	T

Synthesis Route

(1R,2S,4aR,13bS,14aS)-methyl-2-hydroxy-1,2,4a,5,7,8,13,13b,14,14a-decahydroindolo[2',3':3,4]pyrido-[1,2-b]isoquinoline-1-carboxylate→Yohimbine
(+)-yohimbinone→Yohimbine
(20β)-18,19-didehydroyohimban-17-one→Yohimbine

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Packed	SE-30	280.	3150.	isothermal
Capillary	SE-30	-	3168.	temperature ramp
Packed	OV-1	-	3130.	temperature ramp
Packed	SE-30	-	3175.	temperature ramp

Precursor

(+)-yohimbinone
(20β)-18,19-didehydroyohimban-17-one
(4aS,6S,7R,8aR)-2-(2-(1H-indol-3-yl)ethyl)-7-hydroxy-3-oxodecahydroisoquinolin-6-yl pivalate
(1R,2S,4aR,13bS,14aS)-methyl-2-hydroxy-1,2,4a,5,7,8,13,13b,14,14a-decahydroindolo[2',3':3,4]pyrido-[1,2-b]isoquinoline-1-carboxylate

Downstream Product

Indole-2-carboxylic acid
3-ethyl-1H-indole
isoquinoline
(2R)-2-(2,4,5-trichlorophenoxy)propanoic acid

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