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YANGONIN

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Origin: China

Cas No: 500-62-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 500-62-9 Formula: C15H14O4 Molecular Weight: 258.26900

Description

Yangonin is one of the six major kavalactones found in the kava plant. It has been shown to possess binding affinity for the cannabinoid receptor CB1 (Ki = 0.72 μM), where it behaves as an agonist.

Basic Info

Chemical Name	YANGONIN
Synonyms	4-Methoxy-6-((E)-4-methoxystyryl)pyran-2-one;
CAS No.	500-62-9
Molecular Formula	C15H14O4
Molecular Weight	258.26900
PSA	48.67000
LogP	2.82740

Properties

Appearance & Physical State	pale yellow powder
Density	1.2 g/cm3
Boiling Point	487.6ºC at 760 mmHg
Melting Point	155-157ºC
Flash Point	219.8ºC
Refractive Index	1.577

Safety Info

HS Code	2932999099

Synthesis Route

(E)-4-methoxy-6-(4-methoxystyryl)-5,6-dihydro-2H-pyran-2-one→YANGONIN
(4-Methoxy-2-oxo-2H-pyran-6-yl)methyltriphenylphosphonium Bromide+Anisic aldehyde→YANGONIN
triacetate lactone→YANGONIN

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	>1500 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	>1500 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Intravenous	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	41 mg/kg	1.Behavioral-anticonvulsant