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vardenafil

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Origin: China

Cas No: 224785-90-4

Specification: 99%min

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Supply Ability: 80 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 224785-90-4 Formula: C23H34Cl2N6O4S Molecular Weight: 561.52500

    Description

    Vardenafil (INN) is a PDE5 inhibitor used for treating erectile dysfunction that is sold under the trade names Levitra (Bayer AG, GSK, and SP), Staxyn in India, and Vivanza in Italy.

    Basic Info

    Chemical Name vardenafil
    Synonyms

    4-[2-ethoxy-5-(4-ethyl-piperazine-1-sulfonyl)-phenyl]-9-methyl-7-propyl-3,5,6,8-tetrazabicyclo[4.3.0]nona-3,7,9-trien-2-one;
    Vardenafil (INN);
    Vardenafil hydrochloride trihydrate;
    [14C]-Vardenafil;
    2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one;
    Vivanza;
    Vardenafil HCl Trihydrate;
    Vardenafil;
    4-[2-eyhoxy-5-(4-ethylpiperazin-1-yl)sulfonyl-phenyl]-9-methyl-7-propyl-3,5,6,8-tetrazabicyclo[4,3,0] none 3,7,9 trien-2-one;
    Levitra (TN);

    CAS No. 224785-90-4
    Molecular Formula C23H34Cl2N6O4S
    Molecular Weight 561.52500
    PSA 121.28000
    LogP 4.63100

    Properties

    Appearance & Physical State White crystalline powder
    Density 1.37g/cm3
    Boiling Point 692.2ºC at 760mmHg
    Melting Point 214-216ºC
    Flash Point 372.5ºC
    Vapor Pressure 5.17E-19mmHg at 25°C

    Synthesis Route

    1-Ethylpiperazine+2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one→vardenafil
    1-Ethylpiperazine+4-ethoxy-3-(5-methyl-4-oxo-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-2-yl)benzenesulfonyl chloride→vardenafil
    2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one→vardenafil

    Precursor

    2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
    4-ethoxy-3-(5-methyl-4-oxo-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-2-yl)benzenesulfonyl chloride
    1-Ethylpiperazine

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