Home > Organosilicon Compounds> trimethyl-[2-[[4-(1H-pyrazol-4-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane

trimethyl-[2-[[4-(1H-pyrazol-4-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane

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Origin: China

Cas No: 941685-27-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details

CAS No.:: 941685-27-4

Other Names:: -(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)

MF:: C15H21N5OSi

EINECS No.:: 941685-27-4

Place of Origin:: China

Type:: Agrochemical Intermediates, Dyestuff Intermediates, Flavor & Fragrance Intermediates, Pharmaceutical Intermediates, Syntheses Material Intermediates

Purity:: ≥99%

Brand Name:: Finerchem

Model Number:: 941685-27-4

Application:: Barractini intermediate

Appearance:: White Powder

Product name:: 4-(1H-Pyrazol-4-yl)-7-[[2-(trimethylsily

CAS:: 941685-27-4

Color:: White Powder

Packaging&Delivery

Packaging Details: Aluminium foil bag for within 10kg, 25kg/Fiber drum, 25kg/kraft bag

Port: SHANGHAI, QINGDAO , BEIJING, SHENZHEN , DALIAN

Lead Time:

Quantity(Kilograms)	1 - 500	>500
Est. Time(days)	4	To be negotiated

Products Description

Product Name	4-(1H-Pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine
CAS No.	941685-27-4
Appearance	White Powder
Assay	≥99%
Capacity	200mt/year
Min.packing	1gram
Application	Barractini intermediate
Standard	Export
Brand	Finerchem
More information	Molecular Formula: C15H21N5OSi Molecular Weight: 315.45 CAS Registry Number: 941685-27-4 Solubility: Insuluble (1.0E-3 g/L) (25ºC), Calc. Density: 1.20±0.1 g/cm3 (20 ºC 760 Torr), Calc.

Property

CAS No.: 941685-27-4 Formula: C15H21N5OSi Molecular Weight: 315.44600

Description

4-(1H-Pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine is an important intermediate in the preparation of the janus kinase inhibitor INCB018424.

Basic Info

Chemical Name	trimethyl-[2-[[4-(1H-pyrazol-4-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane
Synonyms	4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine; 4-(1H-pyrazol-4-yl)-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine;
CAS No.	941685-27-4
Molecular Formula	C15H21N5OSi
Molecular Weight	315.44600
PSA	68.62000
LogP	3.13370

Safety Info

HS Code	2933990090

Synthesis Route

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole+4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine→trimethyl-[2-[[4-(1H-pyrazol-4-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane
(3S)-3-cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile→trimethyl-[2-[[4-(1H-pyrazol-4-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane
4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine+1-(1-Ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole→trimethyl-[2-[[4-(1H-pyrazol-4-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane

Precursor

1-(1-Ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
4-(1-(1-ethoxyethyl)-1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

Downstream Product

Ruxolitinib
(3R)-3-Cyclopentyl-3-[4-(1H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyra zol-1-yl]propanenitrile (2Z)-2-butenedioate (1:1)
ruxolitinib phosphate

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