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pyrrolidin-2-one

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Origin: China

Cas No: 616-45-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 616-45-5 Formula: C4H7NO Molecular Weight: 85.10450

Description

2-Pyrrolidone is an organic compound consisting of a 5-membered lactam, making it the simplest γ-lactam. It is a colorless liquid that is miscible with water and most common organic solvents.
It is produced industrially by treating butyrolactone with ammonia. Alternative routes include the partial hydrogenation of succinimide and the carbonylation of allylamine with methyl amine. 2-Pyrrolidone is an intermediate in the production of vinylpyrrolidone and the drug piracetam.

Basic Info

Chemical Name	pyrrolidin-2-one
Synonyms	2-Pyrrolidinone; 2-oxopyrrolidine; azacyclopentan-2-one; 1-azacyclopentan-2-one;
CAS No.	616-45-5
Molecular Formula	C4H7NO
Molecular Weight	85.10450
PSA	29.10000
LogP	0.22520

Properties

Appearance & Physical State	clear colorless liquid or low melting solid
Density	1.103
Boiling Point	250ºC
Melting Point	25.5ºC
Flash Point	138ºC
Refractive Index	1.486-1.488
Water Solubility	miscible
Vapor Density	2.9 (vs air)

Safety Info

RTECS	UY5715000
Hazard Class	6.1(b)
Safety Statements	S24/25
HS Code	2933790090
Packing Group	III
WGK Germany	1
RIDADR	2810
Risk Statements	R22
Symbol	GHS07
Signal Word	Warning
Hazard Declaration	H319
Caution Statement	P305 + P351 + P338

Synthesis Route

L-glutamic acid→2-Methyl-1H-pyrrole+pyrrolidin-2-one
N-benzyl-3,4-dihydro-2H-pyrrol-5-amine→pyrrolidin-2-one+4-amino-N-benzylbutyramide
aniracetam→pyrrolidin-2-one+4-methoxybenzoic acid

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Capillary	DB-5	-	1076.	temperature ramp
Capillary	HP-5MS	-	1077.	temperature ramp
Capillary	HP-5MS	-	1059.9	custom temperature program
Capillary	Supelcowax-10	-	2002.	temperature ramp
Capillary	DB-Wax	-	2029.	temperature ramp

Precursor

1-benzoylpyrrolidin-2-one
AMMONIUM SUCCINATE
4-Amino-1-butanol
maleimide

Downstream Product

(2-oxopyrrolidin-1-yl)methyl acetate
4-(2,4-dinitroanilino)butanoic acid
tert-butyl 2-ethoxypyrrolidine-1-carboxylate
1-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]pyrrolidin-2-one

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