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granisetron

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Origin: China

Cas No: 109889-09-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 109889-09-0 Formula: C18H21D3N4O Molecular Weight: 315.42800

Description

Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors.
Granisetron was developed by chemists working at the British drug company Beecham around 1988 and is available as a generic. It is produced by Roche Laboratories under the trade name Kytril. The drug was approved in the United Kingdom in 1991 and in United States in 1994 by the FDA.
A granisetron transdermal patch with the trade name Sancuso was approved by the US FDA on September 12, 2008. Sancuso is manufactured by 3M Drug Delivery Systems Division in St. Paul, MN, for ProStrakan, Inc., a pharmaceutical company headquartered in Bedminster, NJ, with global headquarters in Scotland.
Granisetron is metabolized slowly by the liver, giving it a longer than average half-life. One dose usually lasts 4 to 9 hours and is usually administered once or twice daily. This drug is removed from the body by the liver and kidneys.

Basic Info

Chemical Name	granisetron
Synonyms	Kevatril; BIDD:GT0272; Sancuso; [3H]-Granisetron; UNII-WZG3J2MCOL; 1-methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide; HMS2089P14; granisetron hydrochloride;
CAS No.	109889-09-0
Molecular Formula	C18H21D3N4O
Molecular Weight	315.42800
PSA	50.16000
LogP	2.64720

Properties

Density	1.33g/cm3
Boiling Point	532ºC at 760mmHg
Flash Point	275.6ºC

Safety Info

HS Code	2934999090

Synthesis Route

exo-3-Amino-9-methyl-9-azabicyclo[3,3,1]nonane+1-methylindazole-3-carbonyl chloride→granisetron
1-Methylindazole-3-carboxylic acid→granisetron
Granisetron hydrochloride→granisetron

Precursor

1-methylindazole-3-carbonyl chloride
exo-3-Amino-9-methyl-9-azabicyclo[3,3,1]nonane
Granisetron hydrochloride
1-Methylindazole-3-carboxylic acid

Downstream Product

Granisetron hydrochloride

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