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Home > All categories> Biochemicals and Pharmaceutical Chemicals> Active Pharmaceutical Ingredients (APIs)> Respiratory system> diphenylpyraline
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diphenylpyraline

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Origin: China

Cas No: 147-20-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 147-20-6 Formula: C19H23NO Molecular Weight: 281.39200

    Description

    Diphenylpyraline (DPP; sold as Allergen, Arbid, Belfene, Diafen, Hispril, Histyn, Lergobine, Lyssipol, Mepiben, Neargal) is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class. It is marketed in Europe for the treatment of allergies. DPP has also been found to act as a dopamine reuptake inhibitor and produces hyperactivity in rodents. It has been shown to be useful in the treatment of Parkinsonism.

    Basic Info

    Chemical Name diphenylpyraline
    Synonyms

    Hispril;
    N-methyl-4-(diphenylmethoxy)piperidine;
    Neargal;
    Lergobine;
    Belfene;
    Dayfen;
    4-benzhydryloxy-1-methyl-piperidine;
    Histyn;
    Mepiben;
    4-Benzhydryloxy-1-methyl-piperidin;
    4-Diphenylmethoxy-1-methyl-piperidin;
    4-(diphenylmethoxy)-1-methylpiperidine;
    Lyssipoll;
    Allergen;
    4-benzhydryloxy-1-methylpiperidine;

    CAS No. 147-20-6
    Molecular Formula C19H23NO
    Molecular Weight 281.39200
    PSA 12.47000
    LogP 3.82470

    Properties

    Density 1.08 g/cm3
    Boiling Point 378.7ºC at 760 mmHg
    Flash Point 111.6ºC
    Refractive Index 1.587
    Vapor Pressure 6.18E-06mmHg at 25°C

    Safety Info

    Hazard Class 6.1(b)
    HS Code 2933399090
    Packing Group III
    RIDADR UN 3249

    Synthesis Route

    N-Methyl-4-piperidinol+Bromodiphenylmethane→diphenylpyraline
    N-Methyl-4-piperidinol+Chlorodiphenylmethane→diphenylpyraline
    N-Methyl-4-piperidinol+diazodiphenylmethane→diphenylpyraline

    Precursor

    Bromodiphenylmethane
    N-Methyl-4-piperidinol
    diazodiphenylmethane
    Chlorodiphenylmethane

    Downstream Product

    4-benzhydryloxypiperidine
    ethyl 4-benzhydryloxypiperidine-1-carboxylate

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