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Главная > All categories> Biochemicals and Pharmaceutical Chemicals> Active Pharmaceutical Ingredients (APIs)> Gastrointestinal tract/ metabolism> ciglitazone
Изображение ciglitazone

ciglitazone

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начало: Китай

Кас Но: 74772-77-3

Спецификация: 99%наименьший

минимальный объем заказа: 1 /kg

снабженческая способность: 50 mt/month

опережающий период: OEM 7 дней, пятно 3 дня

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  • Характеристики продукции
  • Описание продукта

  • Property

    CAS No.: 74772-77-3 Formula: C18H23NO3S Molecular Weight: 333.44500

    Description

    Ciglitazone (INN) is a thiazolidinedione. Developed by Takeda Pharmaceuticals in the early 1980s, it is considered the prototypical compound for the thiazolidinedione class.
    Ciglitazone was never used as a medication, but it sparked interest in the effects of thiazolidinediones. Several analogues were later developed, some of which—such as pioglitazone and troglitazone—made it to the market.
    Ciglitazone significantly decreases VEGF production by human granulosa cells in an in vitro study, and may potentially be used in ovarian hyperstimulation syndrome. Ciglitazone is a potent and selective PPARγ ligand. It binds to the PPARγ ligand-binding domain with an EC50 of 3.0 µM. Ciglitazone is active in vivo as an anti-hyperglycemic agent in the ob/ob murine model. Inhibits HUVEC differentiation and angiogenesis and also stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells.

    Basic Info

    Chemical Name ciglitazone
    Synonyms

    CIGLITIZONE;
    CIGLITLZONE;
    Ciglitazone;
    Flurofamide;
    AD-4533;
    ADD 3878;
    Ciglitazone,5-[[4-[(1-Methylcyclohexyl)methoxy]phenyl]methyl]-2,4-thiazolidinedione;

    CAS No. 74772-77-3
    Molecular Formula C18H23NO3S
    Molecular Weight 333.44500
    PSA 80.70000
    LogP 4.25870

    Properties

    Appearance & Physical State white cyrstalline solid
    Density 1.189 g/cm3
    Boiling Point 504.5ºC at 760 mmHg
    Melting Point 130-131ºC
    Flash Point 258.9ºC
    Refractive Index 1.568
    Storage Condition Store at RT

    Safety Info

    WGK Germany 3

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral TDLo - Lowest published toxic dose Rodent - mouse 950 mg/kg,female 1-19 day(s) after conception 1.Reproductive-Fertility-litter size (e.g. # fetuses per litter; measured before birth)

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