Home > All categories> Biochemicals and Pharmaceutical Chemicals> Active Pharmaceutical Ingredients (APIs)> Cardiovascular system> (4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid

(4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid

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Origin: China

Cas No: 88768-40-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
88768-40-5
Other Names:
Cilazapril
MF:
C22H31N3O5
EINECS No.:
BULL
Place of Origin:
Shaanxi, China
Type:
Cardiovascular Agents
Grade Standard:
Medicine Grade
Usage:
Animal Pharmaceuticals
Brand Name:
GK
Model Number:
GK2020
Purity:
99%min
Molecular Weight:
417.50
Density:
1.26 g/cm3
Melting Point:
95-97 °C
Boiling Point:
598.1 °C at 760 mmHg
Packaging&Delivery
Packaging Details
1g/BAG,500g/BAG,25kg/DRUM
Port
tianjin or shanghai port
Lead Time:
Quantity(Milligrams) 1 - 1 2 - 10 >10
Est. Time(days) 5 15 To be negotiated

Property

CAS No.: 88768-40-5 Formula: C22H31N3O5 Molecular Weight: 417.49900

Description

Cilazapril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive heart failure. It is branded as Dynorm, Inhibace, Vascace and many other names in various countries. None of these are available in the United States as of May 2010.
Of the eight possible stereoisomers, only the all-(S)-form is medically viable.

Basic Info

Chemical Name	(4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid
Synonyms	Ro 34-2848; (1S,9S)-9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid; 9(S)-[1-(S)-(ethoxycarbony)-3-phenylpropylamino]octahydro-10-oxo-6H-pyridazo[1,2-a][1,2]-diazepine-1(S)-carboxylic acid; (1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid; Cilazaprilum [Latin]; Cilazaprilum; Cilazil;
CAS No.	88768-40-5
Molecular Formula	C22H31N3O5
Molecular Weight	417.49900
PSA	99.18000
LogP	1.86220

Properties

Appearance & Physical State	Off-White Solid
Density	1.26g/cm3
Boiling Point	598.1ºC at 760 mmHg
Melting Point	95-97ºC
Flash Point	315.5ºC
Refractive Index	1.591
Storage Condition	2-8ºC
Vapor Pressure	3.73E-15mmHg at 25°C

Safety Info

RTECS	MJ9650200
Safety Statements	S22; S24/25

Synthesis Route

(1S,9S)-t-butyl 9-((1S)-ethoxycarbonyl-3-phenylpropylamino)octahydro-10-oxo-6H-pyridazino(1,2-a)(1,2)diazepine-1-carboxylate→(4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid
(R)-2-Hydroxy-4-phenylbutyric acid→(4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid
(S)-benzyl 5-chloro-4-(1,3-dioxoisoindolin-2-yl)-5-oxopentanoate→(4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid

Precursor

(1S,9S)-t-butyl 9-((1S)-ethoxycarbonyl-3-phenylpropylamino)octahydro-10-oxo-6H-pyridazino(1,2-a)(1,2)diazepine-1-carboxylate
(S)-benzyl 5-chloro-4-(1,3-dioxoisoindolin-2-yl)-5-oxopentanoate
(S)-2-[(S)-4-Benzyloxycarbonyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyryl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester
(S)-1-Benzyl 3-tert-butyl tetrahydropyridazine-1,3(2H)-dicarboxylate

Downstream Product

Ethanol
(4S,7S)-7-[[(1S)-1-carboxy-3-phenylpropyl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid

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