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Picture of 4-Chloro-2-trifluoroacetylaniline

4-Chloro-2-trifluoroacetylaniline

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Origin: China

Cas No: 154598-53-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 154598-53-5 Formula: C8H5ClF3NO Molecular Weight: 223.58000

    Description

    An intermediate in the synthesis of Efavirenz-d4.

    Basic Info

    Chemical Name 4-Chloro-2-trifluoroacetylaniline
    Synonyms

    1-(2-AMINO-5-CHLOROPHENYL)-2,2,2-TRIFLUOROETHANONE;

    CAS No. 154598-53-5
    Molecular Formula C8H5ClF3NO
    Molecular Weight 223.58000
    PSA 43.09000
    LogP 3.24840

    Properties

    Appearance & Physical State Yellow solid
    Density 1.475g/cm3
    Boiling Point 282.279ºC at 760 mmHg
    Melting Point 95-97ºC
    Flash Point 124.518ºC
    Refractive Index 1.517
    Vapor Pressure 0.003mmHg at 25°C

    Safety Info

    HS Code 2922399090

    Synthesis Route

    N-[4-chloro-2-(2,2,2-trifluoroacetyl)phenyl]-2,2-dimethylpropanamide4-Chloro-2-trifluoroacetylaniline
    4-Chloro-2-(trifluoroacetyl)aniline hydrochloride4-Chloro-2-trifluoroacetylaniline
    6-chloro-2-methyl-3,1-benzoxazin-4-one+(Trifluoromethyl)trimethylsilane4-Chloro-2-trifluoroacetylaniline

    Precursor

    6-chloro-2-methyl-3,1-benzoxazin-4-one
    4-Chloro-2-(trifluoroacetyl)aniline hydrochloride
    (Trifluoromethyl)trimethylsilane
    Ethyl trifluoroacetate

    Downstream Product

    1-(2-Aminophenyl)-2,2,2-trifluoroethanone
    N-[4-chloro-2-(2,2,2-trifluoroacetyl)phenyl]-2,2-dimethylpropanamide
    (S)-1-(2-Amino-5-chlorophenyl)-1-(trifluoromethyl)-3-cyclopropyl-2-propyn-1-ol
    efavirenz

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