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4-Amino-5-fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl ]-2(1H)-pyrimidinone

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Origin: China

Cas No: 137530-41-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 137530-41-7 Formula: C8H10FN3O3S Molecular Weight: 247.24700

Description

A reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine.

Basic Info

Chemical Name	4-Amino-5-fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl ]-2(1H)-pyrimidinone
Synonyms	4-Amino-5-ethyl-2,4-dihydro-3H-1,2,4-triazol-3-one; 3-ethyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-one; 2',3'-dideoxy-3'-thia-5-fluorocytidine; 3H-1,2,4-Triazol-3-one,4-amino-5-ethyl-2,4-dihydro;
CAS No.	137530-41-7
Molecular Formula	C8H10FN3O3S
Molecular Weight	247.24700
PSA	116.66000
LogP	-0.11260

Synthesis Route

(+)-(2S,5R)-5-fluoro-1-[2-[[(tert-butyldiphenylsilyl)oxy]methyl]-1,3-oxathiolan-5-yl]-N4-benzoylcytosine→4-Amino-5-fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl ]-2(1H)-pyrimidinone

Precursor

(+)-(2S,5R)-5-fluoro-1-[2-[[(tert-butyldiphenylsilyl)oxy]methyl]-1,3-oxathiolan-5-yl]-N4-benzoylcytosine

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