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3-methylbutyl 7,8-dimethyl-4,5-dioxo-6H-pyrano[3,2-c]quinoline-2-carboxylate

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Origin: China

Cas No: 73080-51-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 73080-51-0 Formula: C20H21NO5 Molecular Weight: 355.38400

Description

Repinirast (INN; marketed under the tradename Romet) is an antihistamine.

Basic Info

Chemical Name	3-methylbutyl 7,8-dimethyl-4,5-dioxo-6H-pyrano[3,2-c]quinoline-2-carboxylate
Synonyms	Isoamyl 5,6-dihydro-7,8-dimethyl-4,5-dioxo-4H-pyrano(3,2-c)quinoline-2-carboxylate; MY-5116; Repirinastum [INN-Latin]; Romet; Isopentyl 5,6-dihydro-7,8-dimethyl-4,5-dioxo-4H-pyrano(3,2-c)quinoline-2-carboxylate; repirinast;
CAS No.	73080-51-0
Molecular Formula	C20H21NO5
Molecular Weight	355.38400
PSA	89.37000
LogP	3.45420

Properties

Density	1.27g/cm3
Boiling Point	581.3ºC at 760 mmHg
Flash Point	305.4ºC
Refractive Index	1.592

Safety Info

HS Code	2934999090

Synthesis Route

3-acetyl-4-hydroxy-7,8-dimethyl-1H-quinolin-2-one→3-methylbutyl 7,8-dimethyl-4,5-dioxo-6H-pyrano[3,2-c]quinoline-2-carboxylate
2,3-Dimethylaniline→3-methylbutyl 7,8-dimethyl-4,5-dioxo-6H-pyrano[3,2-c]quinoline-2-carboxylate
7,8-dimethyl-4,5-dioxo-6H-pyrano[3,2-c]quinoline-2-carboxylic acid→3-methylbutyl 7,8-dimethyl-4,5-dioxo-6H-pyrano[3,2-c]quinoline-2-carboxylate

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	>5 gm/kg	1.Behavioral-food intake (animal) 2.Nutritional and Gross Metabolic-weight loss or decreased weight gain
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - rat	2783 mg/kg	1.Gastrointestinal-peritonitis 2.Kidney, Ureter, Bladder-other changes
Subcutaneous	LD50 - Lethal dose, 50 percent kill	Rodent - rat	>5 gm/kg	1.Behavioral-food intake (animal) 2.Skin and Appendages-dermatitis, other (after systemic exposure) 3.Nutritional and Gross Metabolic-weight loss or decreased weight gain

Precursor

isoamylol
QUINOLINE-2-CARBONYL CHLORIDE
7,8-dimethyl-4,5-dioxo-6H-pyrano[3,2-c]quinoline-2-carboxylic acid
2,3-Dimethylaniline

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