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2-Acetylphenothiazine

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Origin: China

Cas No: 6631-94-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 6631-94-3 Formula: C14H11NOS Molecular Weight: 241.30800

    Description

    2-Acetylphenothiazine is a potent and selective NADPH oxidase 1 (NOX1) inhibitor that blocks NOX1-dependent ROS generation. 2-Acetylphenothiazine has been shown to inhibit SrcYF-induced invadopodia formation in human DLD1 colon cancer cells.

    Basic Info

    Chemical Name 2-Acetylphenothiazine
    Synonyms

    2-acetyl-1-phenothiazine;
    2-Acetyl-10H-phenothiazine;
    1-phenothiazin-2-yl-ethanone;
    2-acetyl-phenothiazine;
    1-(10H-phenothiazin-2-yl)ethanone;
    methyl phenothiazin-2-yl ketone;

    CAS No. 6631-94-3
    Molecular Formula C14H11NOS
    Molecular Weight 241.30800
    PSA 54.40000
    LogP 4.23540

    Properties

    Appearance & Physical State mustard-colored powder
    Density 1.249 g/cm3
    Boiling Point 455.7ºC at 760 mmHg
    Melting Point 180-185ºC
    Flash Point 229.4ºC
    Refractive Index 1.653

    Safety Info

    HS Code 2934300000
    WGK Germany 3
    Symbol GHS07
    Signal Word Warning
    Hazard Declaration H302; H412
    Caution Statement P273

    Synthesis Route

    1-(10-acetylphenothiazin-2-yl)ethanone→2-Acetylphenothiazine
    1-phenothiazin-10-ylethanone→2-Acetylphenothiazine
    10H-phenothiazine→2-Acetylphenothiazine

    Precursor

    acetyl chloride
    1-(10-acetylphenothiazin-2-yl)ethanone
    1-phenothiazin-10-ylethanone
    10H-phenothiazine

    Downstream Product

    2-ethenyl-10H-phenothiazine
    acepromazine
    1-[10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazin-2-yl]ethanone
    3-(Dimethylamino)-1-(10H-phenothiazin-2-yl)-2-propen-1-one

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