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sunitinib

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Origin: China

Cas No: 557795-19-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 557795-19-4 Formula: C22H23D4FN4O2 Molecular Weight: 402.49800

Description

Sunitinib is a multi-kinase inhibitor targeting several receptor tyrosine kinases (RTK). Antineoplastic.

Basic Info

Chemical Name	sunitinib
Synonyms	5-(5-Fluoro-2-oxo-1,2-Dihydroindol-3-Ylidenemethyl)-2,4-Dimethyl-1H-Pyrrole-3-Carboxylic Acid (2-Diethylamino-Ethyl)Amide; Sunitinib; Suniti; N-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide; SUNITINIB-D4; Sutent-d4; SUNITINIB BASE; SUNITINIB MALEATE;
CAS No.	557795-19-4
Molecular Formula	C22H23D4FN4O2
Molecular Weight	402.49800
PSA	77.23000
LogP	3.86380

Properties

Appearance & Physical State	yellow solid
Density	1.229 g/cm3
Boiling Point	572.1ºC at 760 mmHg
Melting Point	189-191ºC
Flash Point	299.8ºC

Synthesis Route

N,N-Diethylethylenediamine+5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid→sunitinib
5-Fluoro-2-oxindole+N-[2-(diethylamino)ethyl]-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide→sunitinib
5-Fluoro-2-oxindole+(Chloromethylene)dimethyliminium chloride→sunitinib

Precursor

5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
5-Fluoro-2-oxindole
N-[2-(diethylamino)ethyl]-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
(Chloromethylene)dimethyliminium chloride

Downstream Product

Sunitinib Malate

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