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sulfamethoxazole

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Origin: China

Cas No: 723-46-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
723-46-6
Other Names:
Sulfamethoxazole
MF:
C10H11N3O3S
EINECS No.:
211-963-3
Place of Origin:
Shaanxi, China
Type:
Antibiotic and Antimicrobial Agents, Auxiliaries and Other Medicinal Chemicals
Grade Standard:
Cosmetic Grade, Food Grade, Medicine Grade
Usage:
Animal Pharmaceuticals
Brand Name:
Phoenix Tree
Model Number:
FQW0572
Purity:
99%
Appearance:
White fine powder
Shelf Life:
2 Years
Packaging&Delivery
Packaging Details
1-5kg with ziplock plastic bag inside,Aluminum foil bag outside.finally with waterproof bag.
6-15kg with plastic bag inside,Aluminum foil bag outside,finally with carton box.
More than 16kg with plastic bag inside,fiber drum outside according to the extract quantity.
Port
Tianjin/Shanghai/Shenzhen/Xi'an
Lead Time:
Quantity(Kilograms) 1 - 50 51 - 1000 >1000
Est. Time(days) 7 15 To be negotiated

Property

CAS No.: 723-46-6 Formula: C10H11N3O3S Molecular Weight: 253.27800

Description

Sulfamethoxazole (SMZ or SMX), is an antibiotic. It was used for bacterial infections such as urinary tract infections, bronchitis, and prostatitis and is effective against both gram negative and positive bacteria such as Listeria monocytogenes and E. coli.
Common side effects include nausea, vomiting, loss of appetite, and skin rashes. It is a sulfonamide and bacteriostatic. It resembles a component of folic acid. It prevents folic acid synthesis in the bacteria that must synthesize their own folic acid. Mammalian cells, and some bacteria, do not synthesize but require preformed folic acid (vitamin B9), they are therefore insensitive to sulfamethoxazole.
It was introduced to the United States in 1961. It is now mostly used in combination with trimethoprim (abbreviated SMX-TMP). Other names include: sulfamethalazole, sulfisomezole, and sulfamethazole.

Basic Info

Chemical Name	sulfamethoxazole
Synonyms	4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide; Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-; Sulfamethoxazole;
CAS No.	723-46-6
Molecular Formula	C10H11N3O3S
Molecular Weight	253.27800
PSA	106.60000
LogP	3.10100

Properties

Appearance & Physical State	Crystals or white powder
Density	1.462 g/cm3
Boiling Point	482.1ºC at 760 mmHg
Melting Point	166-169ºC
Flash Point	245.4ºC
Stability	Stable, but light sensitive. Incompatible with strong oxidizing agents.
Storage Condition	0-6ºC

Safety Info

RTECS	WP0700000
Safety Statements	S22-S26-S36/37/39
HS Code	2935003000
WGK Germany	2
Risk Statements	R22; R36/37/38
Hazard Codes	Xn
Symbol	GHS07
Hazard Declaration	H315; H317; H319; H335
Caution Statement	P261; P280; P305 + P351 + P338
Signal Word	Warning

Synthesis Route

N-acetylsulfamethoxazole→sulfamethoxazole
N-(5-Methyl-1,2-oxazol-3-yl)-4-nitrobenzenesulfonamide→sulfamethoxazole
4-Nitrobenzenesulfonyl chloride→sulfamethoxazole

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Packed	OV-101	-	2387.	temperature ramp

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	TDLo - Lowest published toxic dose	Human - woman	160 mg/kg/10D-I	1.Endocrine-hypoglycemia
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	6200 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - rat	2690 mg/kg	1.Behavioral-somnolence (general depressed activity) 2.Behavioral-convulsions or effect on seizure threshold 3.Lungs, Thorax, or Respiration-dyspnea

Precursor

4-Nitrobenzenesulfonyl chloride
N-Acetylsulfanilyl chloride
N-acetylsulfamethoxazole
N-(5-Methyl-1,2-oxazol-3-yl)-4-nitrobenzenesulfonamide

Downstream Product

N-acetylsulfamethoxazole
4-[2-(3,5-dioxo-1,2-diphenylpyrazolidin-4-ylidene)hydrazinyl]-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide
4-hydroxy-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide

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