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Succinimidyl-6-(biotinamido) Hexanoate

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Origin: China

Cas No: 72040-63-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 72040-63-2 Formula: C20H30N4O6S Molecular Weight: 454.54000

Description

Succinimidyl-6-(biotinamido) Hexanoate is a biotinylation reagent incorporating an aminocaproyl “spacer”. This can reduce the steric hindrance in binding avidin to some biotinylated compounds when used to biotinylate both the antibody and the carrier in the Protein Avidin-Biotin Capture System. This system avoids the direct interaction of a captured antibody with solid surfaces, such as plastics, which may reduce antigenicity. It has also been used to enhance the detection of DNA on nitrocellulose. Has also been used as a cell surface labelling reagent

Basic Info

Chemical Name	Succinimidyl-6-(biotinamido) Hexanoate
Synonyms	(2,5-dioxopyrrolidin-1-yl) 6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoate;
CAS No.	72040-63-2
Molecular Formula	C20H30N4O6S
Molecular Weight	454.54000
PSA	159.21000
LogP	1.98240

Properties

Appearance & Physical State	White solid
Density	1.35g/cm3
Melting Point	169-171ºC
Refractive Index	1.591
Stability	Moisture Sensitive
Storage Condition	-20ºC

Safety Info

WGK Germany	3

Synthesis Route

N-Hydroxysuccinimide+N-Biotinylcaproic Acid→Succinimidyl-6-(biotinamido) Hexanoate
biotin resistant biotin derivative→Succinimidyl-6-(biotinamido) Hexanoate
biotin-NHS ester→Succinimidyl-6-(biotinamido) Hexanoate

Precursor

N-Hydroxysuccinimide
biotin-NHS ester
6-Aminocaproic acid
N-Biotinylcaproic Acid

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