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stavudine

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Origin: China

Cas No: 3056-17-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 3056-17-5 Formula: C10H12N2O4 Molecular Weight: 224.21300

    Description

    Used as an antiviral. A reverse transcriptase inhibitor.

    Basic Info

    Chemical Name stavudine
    Synonyms

    2',3'-didehydro-3'-deoxythimidine;
    1-(2,3-Dideoxy-Beta-D-Glycero-2-Pentenofuranosyl)Thymine;
    D4T;
    ZERIT;
    Sanilvudine;
    Virostav;
    2',3'-Anhydrothymidine;
    Stavudine;
    Stauvidine;
    Stavir;
    1-(2,3-Dideoxy-β-D-glycero-2-pentenofuranosyl)thymine;
    Avostav;
    2',3'-didehydro-3'-deoxythymidine;
    2',3'-dideoxy-2',3'-didehydrothymine;
    2',3'-dideoxy-2',3'-didehydrothymidine;

    CAS No. 3056-17-5
    Molecular Formula C10H12N2O4
    Molecular Weight 224.21300
    PSA 84.32000
    LogP -0.70910

    Properties

    Appearance & Physical State white powder
    Density 1.374g/cm3
    Melting Point 159-160ºC
    Refractive Index -46 ° (C=0.69, H2O)
    Water Solubility 5-10 g/100 mL at 21 ºC
    Stability Stable. Combustible. Incompatible with strong oxidizing agents.
    Storage Condition -20ºC

    Safety Info

    RTECS XP2075000
    Safety Statements S26-S36
    HS Code 2938901000
    WGK Germany 2
    Risk Statements R36/37/38
    Hazard Codes Xi

    Synthesis Route

    butyllithium+3,5-Anhydrothymidine→+thymine
    Tert-Butyllithium+3,5-Anhydrothymidine→+1-(2,5-dideoxy-β-D-threo-pentofuranosyl)thymine
    stavudine-5'-α-naphthyl O-methoxy-L-alanyl phosphate→1-naphthol+stavudine

    Precursor

    [(2S,5R)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,5-dihydrofuran-2-yl]methyl acetate
    potassium ((2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methanolate
    1-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-D-glycero-pento-2-enofuranosyl]thymine

    Downstream Product

    zidovudine
    1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
    thymine
    hydroxy-[[(2S,5R)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,5-dihydrofuran-2-yl]methoxy]-oxophosphanium

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