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Spinorphin

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Origin: China

Cas No: 137201-62-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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CAS No.: 137201-62-8 Formula: C45H64N8O10 Molecular Weight: 877.03700

Description
Spinorphin is an endogenous, non-classical opioid peptide of the hemorphin family first isolated from the bovine spinal cord (hence the prefix spin-) and acts as a regulator of the enkephalinases, a class of enzymes that break down endogenous the enkephalin peptides. It does so by inhibiting the enzymes aminopeptidase N (APN), dipeptidyl peptidase III (DPP3), angiotensin-converting enzyme (ACE), and neutral endopeptidase (NEP). Spinorphin is a heptapeptide and has the amino acid sequence Leu-Val-Val-Tyr-Pro-Trp-Thr (LVVYPWT). It has been observed to possess antinociceptive, antiallodynic, and anti-inflammatory properties. The mechanism of action of spinorphin has not been fully elucidated (i.e., how it acts to inhibit the enkephalinases), but it has been found to act as an antagonist of the P2X3 receptor, and as a weak partial agonist/antagonist of the FP1 receptor.

Basic Info

Chemical Name Spinorphin

Synonyms

CAS No. 137201-62-8

Molecular Formula C45H64N8O10

Molecular Weight 877.03700

PSA 285.38000

LogP 3.81720

Properties

Density 1.277g/cm3

Boiling Point 1256.3ºC at 760 mmHg

Flash Point 713.6ºC

Refractive Index 1.598

Vapor Pressure 0mmHg at 25°C

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