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sotalol

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Origin: China

Cas No: 3930-20-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 3930-20-9 Formula: C12H20N2O3S Molecular Weight: 272.36400

Description

Sotalol is a drug used in individuals with rhythm disturbances of the heart (cardiac arrhythmias). It is a non-selective competitive beta-adrenergic receptor blocker that also exhibits Class III antiarrhythmic properties. Originally discovered in 1960, sotalol became widely used first as a beta blocker in the 1980s, and its function as an antiarrhythmic drug was discovered soon after. Due to the dual action of sotalol, it is often used preferentially to other beta blockers as treatment for both ventricular fibrillation and ventricular tachycardia.
Trade names for Sotalol include Betapace and Betapace AF (Berlex Laboratories), Sotalex and Sotacor (Bristol-Myers Squibb), and Sotylize (Arbor Pharmaceuticals). The U.S. Food and Drug Administration advises that sotalol only be used for serious arrhythmias, because its prolongation of the QT interval carries a small risk of life-threatening torsade de pointes.

Basic Info

Chemical Name	sotalol
Synonyms	N-(4-(1-Hydroxy-2-(isopropylamino)ethyl)phenyl)methanesulfonamide; Sotalol;
CAS No.	3930-20-9
Molecular Formula	C12H20N2O3S
Molecular Weight	272.36400
PSA	86.81000
LogP	2.63420

Properties

Appearance & Physical State	white crystalline
Density	1.239 g/cm3
Boiling Point	443.3ºC at 760 mmHg
Flash Point	221.9ºC
Refractive Index	1.57

Safety Info

Safety Statements	S26-S36
HS Code	2935009090
Risk Statements	R36/37/38
Hazard Codes	Xi

Synthesis Route

Oxo Sotalol Hydrochloride→sotalol

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	TDLo - Lowest published toxic dose	Human - woman	118 mg/kg/4W-I	1.Cardiac-EKG changes not diagnostic of specified effects 2.Cardiac-pulse rate 3.Cardiac-change in rate
Oral	TDLo - Lowest published toxic dose	Human - man	3429 ug/kg/2D-I	1.Cardiac-pulse rate increase, without fall in BP 2.Cardiac-pulse rate 3.Lungs, Thorax, or Respiration-dyspnea
Oral	LDLo - Lowest published lethal dose	Human - woman	288 mg/kg	1.Behavioral-coma 2.Cardiac-change in rate 3.Vascular-BP lowering not characterized in autonomic section