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Solifenacin

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Origin: China

Cas No: 242478-37-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

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Product Description

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CAS No.: 242478-37-1 Formula: C23H26N2O2 Molecular Weight: 362.46500

Description

Solifenacin (INN, trade name Vesicare) is a medicine of the antimuscarinic class and was developed for treating contraction of overactive bladder with associated problems such as increased urination frequency and urge incontinence. It is manufactured and marketed by Astellas, GlaxoSmithKline and Teva Pharmaceutical Industries.

Basic Info

Chemical Name	Solifenacin
Synonyms	(1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; (1S)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylic acid (3R)-1-azabicyclo[2.2.2]oct-3-yl ester; (1S)-(3R)-1-azabicyclo[2,2,2]oct-3-yl-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate; [(8R)-1-azabicyclo[2.2.2]octan-8-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate; (+)-solifenacin; YM 905; Unii-A8910sqj1u; 3,4-dihydro-1-phenyl-(1S)-2(1H)-Isoquinolinecarboxylic acid (3R)-1-azabicyclo[2.2.2]oct-3-yl ester; (3R)-1-azabicyclo[2.2.2]oct-3-yl (1S)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate; 2(1H)-Isoquinolinecarboxylic acid,3,4-dihydro-1-phenyl-,1-azabicyclo(2.2.2)oct-3-yl ester,(R-(R,S)); (1S,3'R)-quinuclidin-3'-yl 1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate;
CAS No.	242478-37-1
Molecular Formula	C23H26N2O2
Molecular Weight	362.46500
PSA	32.78000
LogP	3.74070

Properties

Density	1.24g/cm3
Boiling Point	505.5ºC at 760 mmHg
Flash Point	259.5ºC
Refractive Index	1.648
Vapor Pressure	2.41E-10mmHg at 25°C

Synthesis Route

ethyl (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate+(3R)-1-azabicyclo[2.2.2]octan-3-ol→Solifenacin
(3R)-1-azabicyclo[2,2,2]oct-3-yl pentafluorophenylcarbonate+1-phenyl-1,2,3,4-tetrahydroisoquinoline→Solifenacin
4-nitrophenyl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate+(3R)-1-azabicyclo[2.2.2]octan-3-ol→Solifenacin

Precursor

1-phenyl-1,2,3,4-tetrahydroisoquinoline
4-nitrophenyl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
ethyl (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate
(3R)-1-azabicyclo[2.2.2]octan-3-ol

Downstream Product

Solifenacin N-Oxide

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